Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need

MC Field, D Horn, AH Fairlamb… - Nature Reviews …, 2017 - nature.com
The WHO recognizes human African trypanosomiasis, Chagas disease and the
leishmaniases as neglected tropical diseases. These diseases are caused by parasitic …

The quest for new approaches in myocarditis and inflammatory cardiomyopathy

S Heymans, U Eriksson, J Lehtonen… - Journal of the American …, 2016 - jacc.org
Myocarditis is a diverse group of heart-specific immune processes classified by clinical and
histopathological manifestations. Up to 40% of dilated cardiomyopathy is associated with …

Pathology and pathogenesis of Chagas heart disease

KM Bonney, DJ Luthringer, SA Kim… - Annual Review of …, 2019 - annualreviews.org
Chagas heart disease is an inflammatory cardiomyopathy that develops in approximately
one-third of people infected with the protozoan parasite Trypanosoma cruzi. One way T …

Chagas disease in Europe: a review for the internist in the globalized world

S Antinori, L Galimberti, R Bianco, R Grande… - European Journal of …, 2017 - Elsevier
Chagas disease (CD) or American trypanosomiasis identified in 1909 by Carlos Chagas,
has become over the last 40 years a global health concern due to the huge migration flows …

[HTML][HTML] Chagas disease research and development: Is there light at the end of the tunnel?

E Chatelain - Computational and structural biotechnology journal, 2017 - Elsevier
Chagas disease, or American trypanosomiasis, is the result of infection by the parasite
Trypanosoma cruzi. It is endemic in Latin America, and spreading around the globe due to …

The unsolved jigsaw puzzle of the immune response in Chagas disease

GR Acevedo, MC Girard, KA Gómez - Frontiers in immunology, 2018 - frontiersin.org
Trypanosoma cruzi interacts with the different arms of the innate and adaptive host's immune
response in a very complex and flowery manner. The history of host-parasite co-evolution …

Chagas disease as example of a reemerging parasite

J Guarner - Seminars in diagnostic pathology, 2019 - Elsevier
Trypanosoma cruzi, the protozoan that causes Chagas disease, is primarily transmitted by
three main Triatomine vectors in endemic areas. However, the infection has become a …

Chagas disease diagnostic applications: present knowledge and future steps

V Balouz, F Agüero, CA Buscaglia - Advances in parasitology, 2017 - Elsevier
Chagas disease, caused by the protozoan Trypanosoma cruzi, is a lifelong and debilitating
illness of major significance throughout Latin America and an emergent threat to global …

Chagas disease: Immunology of the disease at a glance

AC Cristovão-Silva, MCA Brelaz-de-Castro… - Cytokine & Growth …, 2021 - Elsevier
Chagas disease is an important neglected disease that affects 6–7 million people
worldwide. The disease has two phases: acute and chronic, in which there are different …

Autoimmunity in chronic Chagas disease: a road of multiple pathways to cardiomyopathy?

E De Bona, KCF Lidani, L Bavia, Z Omidian… - Frontiers in …, 2018 - frontiersin.org
Chagas disease (CD), a neglected tropical disease caused by the protozoan Trypanosoma
cruzi, affects around six million individuals in Latin America. Currently, CD occurs worldwide …