Ultrasound-mediated blood–brain barrier opening: An effective drug delivery system for theranostics of brain diseases
J Wang, Z Li, M Pan, M Fiaz, Y Hao, Y Yan… - Advanced Drug Delivery …, 2022 - Elsevier
Blood-brain barrier (BBB) remains a significant obstacle to drug therapy for brain diseases.
Focused ultrasound (FUS) combined with microbubbles (MBs) can locally and transiently …
Focused ultrasound (FUS) combined with microbubbles (MBs) can locally and transiently …
Brain‐targeting drug delivery systems
P Liu, C Jiang - Wiley Interdisciplinary Reviews: Nanomedicine …, 2022 - Wiley Online Library
Brain diseases, including neurodegenerative diseases, acute ischemic stroke and brain
tumors, have become a major health problem and a huge burden on society with high …
tumors, have become a major health problem and a huge burden on society with high …
[HTML][HTML] Sonobiopsy for minimally invasive, spatiotemporally-controlled, and sensitive detection of glioblastoma-derived circulating tumor DNA
Though surgical biopsies provide direct access to tissue for genomic characterization of
brain cancer, they are invasive and pose significant clinical risks. Brain cancer management …
brain cancer, they are invasive and pose significant clinical risks. Brain cancer management …
First-in-human prospective trial of sonobiopsy in high-grade glioma patients using neuronavigation-guided focused ultrasound
Sonobiopsy is an emerging technology that combines focused ultrasound (FUS) with
microbubbles to enrich circulating brain disease-specific biomarkers for noninvasive …
microbubbles to enrich circulating brain disease-specific biomarkers for noninvasive …
Focused ultrasound–mediated liquid biopsy in a tauopathy mouse model
Background Neurodegenerative disorders (such as Alzheimer disease) characterized by the
deposition of various pathogenic forms of tau protein in the brain are collectively referred to …
deposition of various pathogenic forms of tau protein in the brain are collectively referred to …
The road ahead to successful BBB opening and drug-delivery with focused ultrasound
M López-Aguirre, M Castillo-Ortiz… - Journal of Controlled …, 2024 - Elsevier
This review delves into the innovative technology of Blood-Brain Barrier (BBB) opening with
low-intensity focused ultrasound in combination with microbubbles (LIFU-MB), a promising …
low-intensity focused ultrasound in combination with microbubbles (LIFU-MB), a promising …
An affordable and easy-to-use focused ultrasound device for noninvasive and high precision drug delivery to the mouse brain
Objective: Focused ultrasound (FUS) combined with microbubble-mediated blood-brain
barrier (BBB) opening (FUS-BBBO) is not only a promising technique for clinical applications …
barrier (BBB) opening (FUS-BBBO) is not only a promising technique for clinical applications …
The Role of Reactive Oxygen Species in Alzheimer's Disease: from Mechanism to Biomaterials Therapy
Z Yu, F Luo - Advanced Healthcare Materials, 2024 - Wiley Online Library
Alzheimer's disease (AD) is a chronic, insidious, and progressive neuro‐degenerative
disease that remains a clinical challenge for society. The fully approved drug lecanemab …
disease that remains a clinical challenge for society. The fully approved drug lecanemab …
Small volume blood-brain barrier opening in macaques with a 1 MHz ultrasound phased array
The use of focused ultrasound to open the blood-brain barrier (BBB) has the potential to
deliver drugs to specific regions of the brain. The size of the BBB opening and ability to …
deliver drugs to specific regions of the brain. The size of the BBB opening and ability to …
[HTML][HTML] Translating ultrasound-mediated drug delivery technologies for CNS applications
Ultrasound enhances drug delivery into the central nervous system (CNS) by opening
barriers between the blood and CNS and by triggering release of drugs from carriers. A key …
barriers between the blood and CNS and by triggering release of drugs from carriers. A key …