The epithelial–mesenchymal plasticity landscape: principles of design and mechanisms of regulation
Epithelial–mesenchymal plasticity (EMP) enables cells to interconvert between several
states across the epithelial–mesenchymal landscape, thereby acquiring hybrid epithelial …
states across the epithelial–mesenchymal landscape, thereby acquiring hybrid epithelial …
Regulation of genome organization and gene expression by nuclear mechanotransduction
C Uhler, GV Shivashankar - Nature reviews Molecular cell biology, 2017 - nature.com
It is well established that cells sense chemical signals from their local microenvironment and
transduce them to the nucleus to regulate gene expression programmes. Although a number …
transduce them to the nucleus to regulate gene expression programmes. Although a number …
A feedforward mechanism mediated by mechanosensitive ion channel PIEZO1 and tissue mechanics promotes glioma aggression
Alteration of tissue mechanical properties is a physical hallmark of solid tumors including
gliomas. How tumor cells sense and regulate tissue mechanics is largely unknown. Here …
gliomas. How tumor cells sense and regulate tissue mechanics is largely unknown. Here …
Tissue mechanics regulate brain development, homeostasis and disease
All cells sense and integrate mechanical and biochemical cues from their environment to
orchestrate organismal development and maintain tissue homeostasis …
orchestrate organismal development and maintain tissue homeostasis …
Regulation of epithelial-mesenchymal transition by tumor microenvironmental signals and its implication in cancer therapeutics
Epithelial–mesenchymal transition (EMT) has been implicated in various aspects of tumor
development, including tumor invasion and metastasis, cancer stemness, and therapy …
development, including tumor invasion and metastasis, cancer stemness, and therapy …
Mechanobiology of macrophages: how physical factors coregulate macrophage plasticity and phagocytosis
N Jain, J Moeller, V Vogel - Annual review of biomedical …, 2019 - annualreviews.org
In addition to their early-recognized functions in host defense and the clearance of apoptotic
cell debris, macrophages play vital roles in tissue development, homeostasis, and repair. If …
cell debris, macrophages play vital roles in tissue development, homeostasis, and repair. If …
Compression-induced dedifferentiation of adipocytes promotes tumor progression
Dysregulated physical stresses are generated during tumorigenesis that affect the
surrounding compliant tissues including adipocytes. However, the effect of physical …
surrounding compliant tissues including adipocytes. However, the effect of physical …
[HTML][HTML] Apoptotic extracellular vesicles are metabolized regulators nurturing the skin and hair
Over 300 billion of cells die every day in the human body, producing a large number of
endogenous apoptotic extracellular vesicles (apoEVs). Also, allogenic stem cell …
endogenous apoptotic extracellular vesicles (apoEVs). Also, allogenic stem cell …
Focal adhesion kinase signaling in unexpected places
EG Kleinschmidt, DD Schlaepfer - Current opinion in cell biology, 2017 - Elsevier
Highlights•FAK undergoes conformational activation and dimerization.•FAK activation can
occur at adhesions, on endosomes, and in the nucleus.•FAK localizes to adherens junctions …
occur at adhesions, on endosomes, and in the nucleus.•FAK localizes to adherens junctions …
Tumor-on-a-chip for integrating a 3D tumor microenvironment: chemical and mechanical factors
Tumor progression, including metastasis, is significantly influenced by factors in the tumor
microenvironment (TME) such as mechanical force, shear stress, chemotaxis, and hypoxia …
microenvironment (TME) such as mechanical force, shear stress, chemotaxis, and hypoxia …