The immunobiology and pathogenesis of celiac disease

R Iversen, LM Sollid - Annual Review of Pathology: Mechanisms …, 2023 - annualreviews.org
Among human leukocyte antigen (HLA)-associated disorders, celiac disease has an
immunopathogenesis that is particularly well understood. The condition is characterized by …

What is gluten?

JR Biesiekierski - Journal of gastroenterology and hepatology, 2017 - Wiley Online Library
Gluten is the main storage protein of wheat grains. Gluten is a complex mixture of hundreds
of related but distinct proteins, mainly gliadin and glutenin. Similar storage proteins exist as …

Low‐gluten, nontransgenic wheat engineered with CRISPR/Cas9

S Sánchez‐León, J Gil‐Humanes… - Plant biotechnology …, 2018 - Wiley Online Library
Coeliac disease is an autoimmune disorder triggered in genetically predisposed individuals
by the ingestion of gluten proteins from wheat, barley and rye. The α‐gliadin gene family of …

Diagnosis and management of adult coeliac disease: guidelines from the British Society of Gastroenterology

JF Ludvigsson, JC Bai, F Biagi, TR Card, C Ciacci… - Gut, 2014 - gut.bmj.com
A multidisciplinary panel of 18 physicians and 3 non-physicians from eight countries
(Sweden, UK, Argentina, Australia, Italy, Finland, Norway and the USA) reviewed the …

TAK-101 nanoparticles induce gluten-specific tolerance in celiac disease: a randomized, double-blind, placebo-controlled study

CP Kelly, JA Murray, DA Leffler, DR Getts, AC Bledsoe… - Gastroenterology, 2021 - Elsevier
Background & aims In celiac disease (CeD), gluten induces immune activation, leading to
enteropathy. TAK-101, gluten protein (gliadin) encapsulated in negatively charged poly (dl …

Celiac disease: a review of current concepts in pathogenesis, prevention, and novel therapies

JA Tye-Din, HJ Galipeau, D Agardh - Frontiers in pediatrics, 2018 - frontiersin.org
Our understanding of celiac disease and how it develops has evolved significantly over the
last half century. Although traditionally viewed as a pediatric illness characterized by …

Current and emerging therapies for coeliac disease

L Kivelä, A Caminero, DA Leffler… - Nature reviews …, 2021 - nature.com
Coeliac disease is a common enteropathy that occurs in genetically susceptible individuals
in response to the ingestion of gluten proteins present in wheat, rye and barley. Currently …

Properties of gluten intolerance: gluten structure, evolution, pathogenicity and detoxification capabilities

AV Balakireva, AA Zamyatnin Jr - Nutrients, 2016 - mdpi.com
Theterm gluten intolerance may refer to three types of human disorders: autoimmune celiac
disease (CD), allergy to wheat and non-celiac gluten sensitivity (NCGS). Gluten is a mixture …

Antigen-specific therapeutic approaches for autoimmunity

P Serra, P Santamaria - Nature biotechnology, 2019 - nature.com
The main function of the immune system in health is to protect the host from infection by
microbes and parasites. Because immune responses to nonself bear the risk of unleashing …

Gluten-related disorders: Celiac disease, wheat allergy, and nonceliac gluten sensitivity

B Cabanillas - Critical reviews in food science and nutrition, 2020 - Taylor & Francis
The consumption of gluten-free products is becoming an increased alimentary habit in the
general population. The scientific unfounded perception suggesting that the avoidance of …