Transglutaminase regulation of cell function
RL Eckert, MT Kaartinen, M Nurminskaya… - Physiological …, 2014 - journals.physiology.org
Transglutaminases (TGs) are multifunctional proteins having enzymatic and scaffolding
functions that participate in regulation of cell fate in a wide range of cellular systems and are …
functions that participate in regulation of cell fate in a wide range of cellular systems and are …
Role of transglutaminase 2 in cell death, survival, and fibrosis
H Tatsukawa, K Hitomi - Cells, 2021 - mdpi.com
Transglutaminase 2 (TG2) is a ubiquitously expressed enzyme catalyzing the crosslinking
between Gln and Lys residues and involved in various pathophysiological events. Besides …
between Gln and Lys residues and involved in various pathophysiological events. Besides …
Defective CFTR induces aggresome formation and lung inflammation in cystic fibrosis through ROS-mediated autophagy inhibition
A Luciani, VR Villella, S Esposito, N Brunetti-Pierri… - Nature cell …, 2010 - nature.com
Accumulation of unwanted/misfolded proteins in aggregates has been observed in airways
of patients with cystic fibrosis (CF), a life-threatening genetic disorder caused by mutations in …
of patients with cystic fibrosis (CF), a life-threatening genetic disorder caused by mutations in …
Cellular functions of tissue transglutaminase
MV Nurminskaya, AM Belkin - International review of cell and molecular …, 2012 - Elsevier
Transglutaminase 2 (TG2 or tissue transglutaminase) is a highly complex multifunctional
protein that acts as transglutaminase, GTPase/ATPase, protein disulfide isomerase, and …
protein that acts as transglutaminase, GTPase/ATPase, protein disulfide isomerase, and …
[HTML][HTML] Transglutaminase 2: a molecular Swiss army knife
S Gundemir, G Colak, J Tucholski… - Biochimica et Biophysica …, 2012 - Elsevier
Transglutaminase 2 (TG2) is the most widely distributed member of the transglutaminase
family with almost all cell types in the body expressing TG2 to varying extents. In addition to …
family with almost all cell types in the body expressing TG2 to varying extents. In addition to …
Tissue transglutaminase: A multifunctional and multisite regulator in health and disease
Z Yao, Y Fan, L Lin, RE Kellems… - Physiological …, 2024 - journals.physiology.org
Tissue transglutaminase (TG2) is a widely distributed multifunctional protein involved in a
broad range of cellular and metabolic functions carried out in a variety of cellular …
broad range of cellular and metabolic functions carried out in a variety of cellular …
Transglutaminase 2 has opposing roles in the regulation of cellular functions as well as cell growth and death
H Tatsukawa, Y Furutani, K Hitomi, S Kojima - Cell death & disease, 2016 - nature.com
Abstract Transglutaminase 2 (TG2) is primarily known as the most ubiquitously expressed
member of the transglutaminase family with Ca 2+-dependent protein crosslinking activity; …
member of the transglutaminase family with Ca 2+-dependent protein crosslinking activity; …
Restoration of CFTR function in patients with cystic fibrosis carrying the F508del-CFTR mutation
DD Stefano, VR Villella, S Esposito, A Tosco, A Sepe… - Autophagy, 2014 - Taylor & Francis
Restoration of BECN1/Beclin 1-dependent autophagy and depletion of SQSTM1/p62 by
genetic manipulation or autophagy-stimulatory proteostasis regulators, such as cystamine …
genetic manipulation or autophagy-stimulatory proteostasis regulators, such as cystamine …
Targeting vascular NADPH oxidase 1 blocks tumor angiogenesis through a PPARα mediated mechanism
S Garrido-Urbani, S Jemelin, C Deffert, S Carnesecchi… - PloS one, 2011 - journals.plos.org
Reactive oxygen species, ROS, are regulators of endothelial cell migration, proliferation and
survival, events critically involved in angiogenesis. Different isoforms of ROS-generating …
survival, events critically involved in angiogenesis. Different isoforms of ROS-generating …
Gastrointestinal complications of cystic fibrosis
D Gelfond, D Borowitz - Clinical Gastroenterology and Hepatology, 2013 - Elsevier
The cystic fibrosis transmembrane regulator protein (CFTR) is an ion channel in the apical
surface of epithelial membranes that regulates other ion channels. Dysfunction of CFTR …
surface of epithelial membranes that regulates other ion channels. Dysfunction of CFTR …