NMR spectroscopy is the only method to access the structural dynamics of biomolecules at
high (atomistic) resolution in their native solution state. However, this method's low …

The development of hyperpolarized bioresponsive probes for magnetic resonance imaging
(MRI) applications is an emerging and rapidly growing topic in chemistry. A wide range of …

Nitroreductase (NTR) is an important biomarker widely used to evaluate the degree of tumor
hypoxia. Although a few optical methods have been reported for detecting nitroreductase at …

We present an integrated, open-source device for parahydrogen-based hyperpolarization
processes in the microtesla field regime with a cost of components of less than $7000. The …

Hyperpolarized magnetic resonance imaging (MRI) contrast agents are revolutionizing the
field of biomedical imaging. Hyperpolarized Xe-129 was recently FDA approved as an …

Hyperpolarized 129Xe gas was FDA‐approved as an inhalable contrast agent for magnetic
resonance imaging of a wide range of pulmonary diseases in December 2022. Despite the …

Hyperpolarized (ie, polarized far beyond the thermal equilibrium) nuclear spins can result in
the radiofrequency amplification by stimulated emission of radiation (RASER) effect. Here …

Pulmonary functional magnetic resonance imaging (PfMRI) provides a way to non-invasively
map and measure the spatial distribution of pulmonary ventilation, perfusion and gas …

13C hyperpolarized pyruvate is an emerging MRI contrast agent for sensing molecular
events in cancer and other diseases with aberrant metabolic pathways. This metabolic …

Dynamic heterogeneity in lung ventilation is an important measure of pulmonary function
and may be characteristic of early pulmonary disease. While standard indices like …