The most commonly used treatment for Parkinson's disease (PD) is levodopa, prescribed in
conjunction with carbidopa. Virtually all patients with PD undergo dopamine replacement …

Synchronous rhythms represent a core mechanism for sculpting temporal coordination of
neural activity in the brain-wide network. This review focuses on oscillations in the cerebral …

Dopamine cell firing can encode errors in reward prediction, providing a learning signal to
guide future behavior. Yet dopamine is also a key modulator of motivation, invigorating …

An important mechanism for large-scale interactions between cortical areas involves
coupling between the phase and the amplitude of different brain rhythms. Could basal …

Synchronised neuronal oscillations at beta frequencies are prevalent in the human motor
system, but their function is unclear. In this Opinion article, we propose that the levels of beta …

Summary Modulations of beta oscillations (13–30 Hz) during normal motor control suggest
that they may act to promote current motor set at the expense of new movements. These …

The neural bases of behavior are often discussed in terms of perceptual, cognitive, and
motor stages, defined within an information processing framework that was originally …

Parkinson's disease is a common and disabling disorder of movement owing to
dopaminergic denervation of the striatum. However, it is still unclear how this denervation …

Chronic dopamine depletion in Parkinson's disease leads to progressive motor and
cognitive impairment, which is associated with the emergence of characteristic patterns of …

At every moment, the natural world presents animals with two fundamental pragmatic
problems: selection between actions that are currently possible and specification of the …