Levodopa-induced dyskinesia in Parkinson's disease: pathogenesis and emerging treatment strategies
The most commonly used treatment for Parkinson's disease (PD) is levodopa, prescribed in
conjunction with carbidopa. Virtually all patients with PD undergo dopamine replacement …
conjunction with carbidopa. Virtually all patients with PD undergo dopamine replacement …
Neurophysiological and computational principles of cortical rhythms in cognition
XJ Wang - Physiological reviews, 2010 - journals.physiology.org
Synchronous rhythms represent a core mechanism for sculpting temporal coordination of
neural activity in the brain-wide network. This review focuses on oscillations in the cerebral …
neural activity in the brain-wide network. This review focuses on oscillations in the cerebral …
Mesolimbic dopamine signals the value of work
Dopamine cell firing can encode errors in reward prediction, providing a learning signal to
guide future behavior. Yet dopamine is also a key modulator of motivation, invigorating …
guide future behavior. Yet dopamine is also a key modulator of motivation, invigorating …
Exaggerated phase–amplitude coupling in the primary motor cortex in Parkinson disease
C De Hemptinne… - Proceedings of the …, 2013 - National Acad Sciences
An important mechanism for large-scale interactions between cortical areas involves
coupling between the phase and the amplitude of different brain rhythms. Could basal …
coupling between the phase and the amplitude of different brain rhythms. Could basal …
New insights into the relationship between dopamine, beta oscillations and motor function
N Jenkinson, P Brown - Trends in neurosciences, 2011 - cell.com
Synchronised neuronal oscillations at beta frequencies are prevalent in the human motor
system, but their function is unclear. In this Opinion article, we propose that the levels of beta …
system, but their function is unclear. In this Opinion article, we propose that the levels of beta …
The functional role of beta oscillations in Parkinson's disease
Summary Modulations of beta oscillations (13–30 Hz) during normal motor control suggest
that they may act to promote current motor set at the expense of new movements. These …
that they may act to promote current motor set at the expense of new movements. These …
Neural mechanisms for interacting with a world full of action choices
P Cisek, JF Kalaska - Annual review of neuroscience, 2010 - annualreviews.org
The neural bases of behavior are often discussed in terms of perceptual, cognitive, and
motor stages, defined within an information processing framework that was originally …
motor stages, defined within an information processing framework that was originally …
Pathological synchronization in Parkinson's disease: networks, models and treatments
Parkinson's disease is a common and disabling disorder of movement owing to
dopaminergic denervation of the striatum. However, it is still unclear how this denervation …
dopaminergic denervation of the striatum. However, it is still unclear how this denervation …
Deep brain stimulation modulates synchrony within spatially and spectrally distinct resting state networks in Parkinson's disease
Chronic dopamine depletion in Parkinson's disease leads to progressive motor and
cognitive impairment, which is associated with the emergence of characteristic patterns of …
cognitive impairment, which is associated with the emergence of characteristic patterns of …
Cortical mechanisms of action selection: the affordance competition hypothesis
P Cisek - … Transactions of the Royal Society B: Biological …, 2007 - royalsocietypublishing.org
At every moment, the natural world presents animals with two fundamental pragmatic
problems: selection between actions that are currently possible and specification of the …
problems: selection between actions that are currently possible and specification of the …