The assembly, regulation and function of the mitochondrial respiratory chain
I Vercellino, LA Sazanov - Nature reviews Molecular cell biology, 2022 - nature.com
The mitochondrial oxidative phosphorylation system is central to cellular metabolism. It
comprises five enzymatic complexes and two mobile electron carriers that work in a …
comprises five enzymatic complexes and two mobile electron carriers that work in a …
[HTML][HTML] Mitochondrial complex I ROS production and redox signaling in hypoxia
CN Okoye, SA Koren, AP Wojtovich - Redox biology, 2023 - Elsevier
Mitochondria are a main source of cellular energy. Oxidative phosphorylation (OXPHOS) is
the major process of aerobic respiration. Enzyme complexes of the electron transport chain …
the major process of aerobic respiration. Enzyme complexes of the electron transport chain …
Oocytes maintain ROS-free mitochondrial metabolism by suppressing complex I
Oocytes form before birth and remain viable for several decades before fertilization.
Although poor oocyte quality accounts for most female fertility problems, little is known about …
Although poor oocyte quality accounts for most female fertility problems, little is known about …
[HTML][HTML] Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context
M Morgenstern, CD Peikert, P Lübbert, I Suppanz… - Cell metabolism, 2021 - cell.com
Mitochondria are key organelles for cellular energetics, metabolism, signaling, and quality
control and have been linked to various diseases. Different views exist on the composition of …
control and have been linked to various diseases. Different views exist on the composition of …
[HTML][HTML] Reactive oxygen species-based nanomaterials for the treatment of myocardial ischemia reperfusion injuries
Interventional coronary reperfusion strategies are widely adopted to treat acute myocardial
infarction, but morbidity and mortality of acute myocardial infarction are still high …
infarction, but morbidity and mortality of acute myocardial infarction are still high …
Investigation of hydrated channels and proton pathways in a high-resolution cryo-EM structure of mammalian complex I
Respiratory complex I, a key enzyme in mammalian metabolism, captures the energy
released by reduction of ubiquinone by NADH to drive protons across the inner …
released by reduction of ubiquinone by NADH to drive protons across the inner …
The coupling mechanism of mammalian respiratory complex I
D Kampjut, LA Sazanov - Science, 2020 - science.org
INTRODUCTION Complex I is the first and, with 45 subunits and a total mass of~ 1 MDa, the
most elaborate of the mitochondrial electron transfer chain enzymes. Complex I converts …
most elaborate of the mitochondrial electron transfer chain enzymes. Complex I converts …
BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis
INTRODUCTION There has been an explosion of interest in the role of cell death pathways
and damage-associated molecular pattern (DAMP) signaling in shaping inflammatory and …
and damage-associated molecular pattern (DAMP) signaling in shaping inflammatory and …
Mitochondrial disorders of the OXPHOS system
E Fernandez‐Vizarra, M Zeviani - FEBS letters, 2021 - Wiley Online Library
Mitochondrial disorders are among the most frequent inborn errors of metabolism, their
primary cause being the dysfunction of the oxidative phosphorylation system (OXPHOS) …
primary cause being the dysfunction of the oxidative phosphorylation system (OXPHOS) …
Integrated multi-omics for rapid rare disease diagnosis on a national scale
Critically ill infants and children with rare diseases need equitable access to rapid and
accurate diagnosis to direct clinical management. Over 2 years, the Acute Care Genomics …
accurate diagnosis to direct clinical management. Over 2 years, the Acute Care Genomics …