The assembly, regulation and function of the mitochondrial respiratory chain

I Vercellino, LA Sazanov - Nature reviews Molecular cell biology, 2022 - nature.com
The mitochondrial oxidative phosphorylation system is central to cellular metabolism. It
comprises five enzymatic complexes and two mobile electron carriers that work in a …

[HTML][HTML] Mitochondrial complex I ROS production and redox signaling in hypoxia

CN Okoye, SA Koren, AP Wojtovich - Redox biology, 2023 - Elsevier
Mitochondria are a main source of cellular energy. Oxidative phosphorylation (OXPHOS) is
the major process of aerobic respiration. Enzyme complexes of the electron transport chain …

Oocytes maintain ROS-free mitochondrial metabolism by suppressing complex I

A Rodríguez-Nuevo, A Torres-Sanchez, JM Duran… - Nature, 2022 - nature.com
Oocytes form before birth and remain viable for several decades before fertilization.
Although poor oocyte quality accounts for most female fertility problems, little is known about …

[HTML][HTML] Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context

M Morgenstern, CD Peikert, P Lübbert, I Suppanz… - Cell metabolism, 2021 - cell.com
Mitochondria are key organelles for cellular energetics, metabolism, signaling, and quality
control and have been linked to various diseases. Different views exist on the composition of …

[HTML][HTML] Reactive oxygen species-based nanomaterials for the treatment of myocardial ischemia reperfusion injuries

T Zhao, W Wu, L Sui, Q Huang, Y Nan, J Liu, K Ai - Bioactive Materials, 2022 - Elsevier
Interventional coronary reperfusion strategies are widely adopted to treat acute myocardial
infarction, but morbidity and mortality of acute myocardial infarction are still high …

Investigation of hydrated channels and proton pathways in a high-resolution cryo-EM structure of mammalian complex I

DN Grba, I Chung, HR Bridges, ANA Agip, J Hirst - Science Advances, 2023 - science.org
Respiratory complex I, a key enzyme in mammalian metabolism, captures the energy
released by reduction of ubiquinone by NADH to drive protons across the inner …

The coupling mechanism of mammalian respiratory complex I

D Kampjut, LA Sazanov - Science, 2020 - science.org
INTRODUCTION Complex I is the first and, with 45 subunits and a total mass of~ 1 MDa, the
most elaborate of the mitochondrial electron transfer chain enzymes. Complex I converts …

BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis

K McArthur, LW Whitehead, JM Heddleston, L Li… - Science, 2018 - science.org
INTRODUCTION There has been an explosion of interest in the role of cell death pathways
and damage-associated molecular pattern (DAMP) signaling in shaping inflammatory and …

Mitochondrial disorders of the OXPHOS system

E Fernandez‐Vizarra, M Zeviani - FEBS letters, 2021 - Wiley Online Library
Mitochondrial disorders are among the most frequent inborn errors of metabolism, their
primary cause being the dysfunction of the oxidative phosphorylation system (OXPHOS) …

Integrated multi-omics for rapid rare disease diagnosis on a national scale

S Lunke, SE Bouffler, CV Patel, SA Sandaradura… - Nature medicine, 2023 - nature.com
Critically ill infants and children with rare diseases need equitable access to rapid and
accurate diagnosis to direct clinical management. Over 2 years, the Acute Care Genomics …