Alterations in the regulation of gene expression are frequently associated with
developmental diseases or cancer. Transcription activation is a key phenomenon in the …

Detection of double-stranded RNAs (dsRNAs) is a central mechanism of innate immune
defense in many organisms. We here discuss several families of dsRNA-binding proteins …

Summary Human immunodeficiency virus (HIV-1) remains a major health threat. Viral capsid
uncoating and nuclear import of the viral genome are critical for productive infection. The …

In a mature, infectious HIV-1 virion, the viral genome is housed within a conical capsid core
made from the viral capsid (CA) protein. The CA protein and the structure into which it …

Host proteins are essential for HIV entry and replication and can be important nonviral
therapeutic targets. Large-scale RNA interference (RNAi)-based screens have identified …

Host dependency factors that are required for influenza A virus infection may serve as
therapeutic targets as the virus is less likely to bypass them under drug-mediated selection …

Animal cells harbour multiple innate effector mechanisms that inhibit virus replication. For
the pathogenic retrovirus human immunodeficiency virus type 1 (HIV-1), these include …

The mutational repertoire of cancers creates the neoepitopes that make cancers
immunogenic. Here, we introduce two novel tools that identify, with relatively high accuracy …

The engineered AAV-PHP. B family of adeno-associated virus efficiently delivers genes
throughout the mouse central nervous system. To guide their application across disease …

Antiviral drugs have traditionally been developed by directly targeting essential viral
components. However, this strategy often fails due to the rapid generation of drug-resistant …