Prospects and challenges of extracellular vesicle-based drug delivery system: considering cell source
W Meng, C He, Y Hao, L Wang, L Li, G Zhu - Drug delivery, 2020 - Taylor & Francis
Extracellular vesicles (EVs), including exosomes, microvesicles, and apoptotic bodies, are
nanosized membrane vesicles derived from most cell types. Carrying diverse biomolecules …
nanosized membrane vesicles derived from most cell types. Carrying diverse biomolecules …
MSC exosome works through a protein-based mechanism of action
Mesenchymal stem cell (MSC) exosome specifically defines the 50–200 nm vesicles that are
secreted into the extracellular space when multivesicular bodies in the MSC fuse with the …
secreted into the extracellular space when multivesicular bodies in the MSC fuse with the …
A nanodrug consisting of doxorubicin and exosome derived from mesenchymal stem cells for osteosarcoma treatment in vitro
H Wei, J Chen, S Wang, F Fu, X Zhu, C Wu… - International journal …, 2019 - Taylor & Francis
Purpose The primary goal of the present study was to develop the nano-drug consisting of
doxorubicin and exosome derived from mesenchymal stem cells, and to explore its effect on …
doxorubicin and exosome derived from mesenchymal stem cells, and to explore its effect on …
MSC exosome as a cell-free MSC therapy for cartilage regeneration: implications for osteoarthritis treatment
Mesenchymal stem cell (MSC) therapies have demonstrated efficacy in cartilage repair in
animal and clinical studies. The efficacy of MSC-based therapies which was previously …
animal and clinical studies. The efficacy of MSC-based therapies which was previously …
Bone marrow-derived mesenchymal stem cells-derived exosomes promote survival of retinal ganglion cells through miRNA-dependent mechanisms
B Mead, S Tomarev - Stem cells translational medicine, 2017 - academic.oup.com
The loss of retinal ganglion cells (RGC) and their axons is one of the leading causes of
blindness and includes traumatic (optic neuropathy) and degenerative (glaucoma) eye …
blindness and includes traumatic (optic neuropathy) and degenerative (glaucoma) eye …
[HTML][HTML] Exosomes/tricalcium phosphate combination scaffolds can enhance bone regeneration by activating the PI3K/Akt signaling pathway
Background Recently, accumulating evidence has shown that exosomes, the naturally
secreted nanocarriers of cells, can exert therapeutic effects in various disease models in the …
secreted nanocarriers of cells, can exert therapeutic effects in various disease models in the …
Mesenchymal stem cell exosomes
MSCs are an extensively used cell type in clinical trials today. The initial rationale for their
clinical testing was based on their differentiation potential. However, the lack of correlation …
clinical testing was based on their differentiation potential. However, the lack of correlation …
[HTML][HTML] Exosomes derived from mesenchymal stem cells
B Yu, X Zhang, X Li - International journal of molecular sciences, 2014 - mdpi.com
The functional mechanisms of mesenchymal stem cells (MSCs) have become a research
focus in recent years. Accumulating evidence supports the notion that MSCs act in a …
focus in recent years. Accumulating evidence supports the notion that MSCs act in a …
[HTML][HTML] Mesenchymal stem cell-derived exosomes increase ATP levels, decrease oxidative stress and activate PI3K/Akt pathway to enhance myocardial viability and …
We have previously identified exosomes as the paracrine factor secreted by mesenchymal
stem cells. Recently, we found that the key features of reperfusion injury, namely loss of …
stem cells. Recently, we found that the key features of reperfusion injury, namely loss of …
Mesenchymal stem cells secrete immunologically active exosomes
Mesenchymal stem cells (MSCs) have been shown to secrete exosomes that are
cardioprotective. Here, we demonstrated that MSC exosome, a secreted membrane vesicle …
cardioprotective. Here, we demonstrated that MSC exosome, a secreted membrane vesicle …