A potent anti-malarial human monoclonal antibody targets circumsporozoite protein minor repeats and neutralizes sporozoites in the liver
LT Wang, LS Pereira, Y Flores-Garcia, J O'Connor… - Immunity, 2020 - cell.com
Discovering potent human monoclonal antibodies (mAbs) targeting the Plasmodium
falciparum circumsporozoite protein (PfCSP) on sporozoites (SPZ) and elucidating their …
falciparum circumsporozoite protein (PfCSP) on sporozoites (SPZ) and elucidating their …
Roles of virtual screening and molecular dynamics simulations in discovering and understanding antimalarial drugs
Malaria continues to be a global health threat, with approximately 247 million cases
worldwide. Despite therapeutic interventions being available, patient compliance is a …
worldwide. Despite therapeutic interventions being available, patient compliance is a …
Application of liposomes in the treatment of infectious diseases
The advances in the development of drugs and vaccines for major infectious diseases of
tuberculosis (TB), malaria and HIV represent some of the most significant milestones in their …
tuberculosis (TB), malaria and HIV represent some of the most significant milestones in their …
A novel CSP C-terminal epitope targeted by an antibody with protective activity against Plasmodium falciparum
Potent and durable vaccine responses will be required for control of malaria caused by
Plasmodium falciparum (Pf). RTS, S/AS01 is the first, and to date, the only vaccine that has …
Plasmodium falciparum (Pf). RTS, S/AS01 is the first, and to date, the only vaccine that has …
An epitope-based malaria vaccine targeting the junctional region of circumsporozoite protein
L Jelínková, H Jhun, A Eaton, N Petrovsky, F Zavala… - npj Vaccines, 2021 - nature.com
A malaria vaccine that elicits long-lasting protection and is suitable for use in endemic areas
remains urgently needed. Here, we assessed the immunogenicity and prophylactic efficacy …
remains urgently needed. Here, we assessed the immunogenicity and prophylactic efficacy …
In vitro and in vivo inhibition of malaria parasite infection by monoclonal antibodies against Plasmodium falciparum circumsporozoite protein (CSP)
MC Livingstone, AA Bitzer, A Giri, K Luo… - Scientific reports, 2021 - nature.com
Plasmodium falciparum malaria contributes to a significant global disease burden.
Circumsporozoite protein (CSP), the most abundant sporozoite stage antigen, is a prime …
Circumsporozoite protein (CSP), the most abundant sporozoite stage antigen, is a prime …
Structural and biophysical correlation of anti-NANP antibodies with in vivo protection against P. falciparum
The most advanced P. falciparum circumsporozoite protein-based malaria vaccine, RTS,
S/AS01 (RTS, S), confers partial protection but with antibody titers that wane relatively …
S/AS01 (RTS, S), confers partial protection but with antibody titers that wane relatively …
Vaccination in a humanized mouse model elicits highly protective PfCSP-targeting anti-malarial antibodies
Repeat antigens, such as the Plasmodium falciparum circumsporozoite protein (PfCSP), use
both sequence degeneracy and structural diversity to evade the immune response. A few …
both sequence degeneracy and structural diversity to evade the immune response. A few …
Restricted valency (NPNA)n repeats and junctional epitope-based circumsporozoite protein vaccines against Plasmodium falciparum
MD Langowski, FA Khan, S Savransky, DR Brown… - npj Vaccines, 2022 - nature.com
Abstract The Circumsporozoite Protein (CSP) of Plasmodium falciparum contains an N-
terminal region, a conserved Region I (RI), a junctional region, 25–42 copies of major …
terminal region, a conserved Region I (RI), a junctional region, 25–42 copies of major …
[HTML][HTML] Molecular determinants of cross-reactivity and potency by VH3-33 antibodies against the Plasmodium falciparum circumsporozoite protein
E Thai, R Murugan, Š Binter, CB Aschner, K Prieto… - Cell Reports, 2023 - cell.com
Summary IGHV3-33-encoded antibodies are prevalent in the human humoral response
against the Plasmodium falciparum circumsporozoite protein (PfCSP). Among VH3-33 …
against the Plasmodium falciparum circumsporozoite protein (PfCSP). Among VH3-33 …