[HTML][HTML] Brain-gut axis dysfunction in the pathogenesis of traumatic brain injury

M Hanscom, DJ Loane… - The Journal of Clinical …, 2021 - Am Soc Clin Investig
Traumatic brain injury (TBI) is a chronic and progressive disease, and management requires
an understanding of both the primary neurological injury and the secondary sequelae that …

Sex differences in traumatic brain injury: what we know and what we should know

RP Gupte, WM Brooks, RR Vukas, JD Pierce… - Journal of …, 2019 - liebertpub.com
There is growing recognition of the problem of male bias in neuroscience research,
including in the field of traumatic brain injury (TBI) where fewer women than men are …

[HTML][HTML] Mer regulates microglial/macrophage M1/M2 polarization and alleviates neuroinflammation following traumatic brain injury

H Wu, J Zheng, S Xu, Y Fang, Y Wu, J Zeng… - Journal of …, 2021 - Springer
Background Traumatic brain injury (TBI) is a leading cause of death and disability
worldwide. Microglial/macrophage activation and neuroinflammation are key cellular events …

Microglial depletion with CSF1R inhibitor during chronic phase of experimental traumatic brain injury reduces neurodegeneration and neurological deficits

RJ Henry, RM Ritzel, JP Barrett, SJ Doran… - Journal of …, 2020 - Soc Neuroscience
Chronic neuroinflammation with sustained microglial activation occurs following severe
traumatic brain injury (TBI) and is believed to contribute to subsequent neurodegeneration …

[HTML][HTML] Microglial activation in traumatic brain injury

CK Donat, G Scott, SM Gentleman… - Frontiers in aging …, 2017 - frontiersin.org
Microglia have a variety of functions in the brain, including synaptic pruning, CNS repair and
mediating the immune response against peripheral infection. Microglia rapidly become …

Animal models of traumatic brain injury

Y Xiong, A Mahmood, M Chopp - Nature Reviews Neuroscience, 2013 - nature.com
Traumatic brain injury (TBI) is a leading cause of mortality and morbidity both in civilian life
and on the battlefield worldwide. Survivors of TBI frequently experience long-term disabling …

[HTML][HTML] Revisiting traumatic brain injury: from molecular mechanisms to therapeutic interventions

A Jarrahi, M Braun, M Ahluwalia, RV Gupta, M Wilson… - Biomedicines, 2020 - mdpi.com
Studying the complex molecular mechanisms involved in traumatic brain injury (TBI) is
crucial for developing new therapies for TBI. Current treatments for TBI are primarily focused …

Neuroinflammatory responses to traumatic brain injury: etiology, clinical consequences, and therapeutic opportunities

D Lozano, GS Gonzales-Portillo, S Acosta… - Neuropsychiatric …, 2015 - Taylor & Francis
Traumatic brain injury (TBI) is a serious public health problem accounting for 1.4 million
emergency room visits by US citizens each year. Although TBI has been traditionally …

[HTML][HTML] Very early administration of progesterone for acute traumatic brain injury

DW Wright, SD Yeatts, R Silbergleit… - … England Journal of …, 2014 - Mass Medical Soc
Background Traumatic brain injury (TBI) is a major cause of death and disability worldwide.
Progesterone has been shown to improve neurologic outcome in multiple experimental …

Long-term consequences of traumatic brain injury: current status of potential mechanisms of injury and neurological outcomes

HM Bramlett, WD Dietrich - Journal of neurotrauma, 2015 - liebertpub.com
Traumatic brain injury (TBI) is a significant clinical problem with few therapeutic interventions
successfully translated to the clinic. Increased importance on the progressive, long-term …