A second space age spanning omics, platforms and medicine across orbits
The recent acceleration of commercial, private and multi-national spaceflight has created an
unprecedented level of activity in low Earth orbit, concomitant with the largest-ever number …
unprecedented level of activity in low Earth orbit, concomitant with the largest-ever number …
Single-cell multi-ome and immune profiles of the Inspiration4 crew reveal conserved, cell-type, and sex-specific responses to spaceflight
Spaceflight induces an immune response in astronauts. To better characterize this effect, we
generated single-cell, multi-ome, cell-free RNA (cfRNA), biochemical, and hematology data …
generated single-cell, multi-ome, cell-free RNA (cfRNA), biochemical, and hematology data …
[HTML][HTML] Targeting the mSWI/SNF complex in POU2F-POU2AF transcription factor-driven malignancies
Summary The POU2F3-POU2AF2/3 transcription factor complex is the master regulator of
the tuft cell lineage and tuft cell-like small cell lung cancer (SCLC). Here, we identify a …
the tuft cell lineage and tuft cell-like small cell lung cancer (SCLC). Here, we identify a …
Secretome profiling reveals acute changes in oxidative stress, brain homeostasis, and coagulation following short-duration spaceflight
As spaceflight becomes more common with commercial crews, blood-based measures of
crew health can guide both astronaut biomedicine and countermeasures. By profiling …
crew health can guide both astronaut biomedicine and countermeasures. By profiling …
Dysregulation of epigenetic modifications in inborn errors of immunity
Z Xiao, R He, Z Zhao, T Chen, Z Ying - Epigenomics, 2024 - Taylor & Francis
Inborn errors of immunity (IEIs) are a group of typically monogenic disorders characterized
by dysfunction in the immune system. Individuals with these disorders experience increased …
by dysfunction in the immune system. Individuals with these disorders experience increased …
SMARCA4 is a haploinsufficient B cell lymphoma tumor suppressor that fine-tunes centrocyte cell fate decisions
SMARCA4 encodes one of two mutually exclusive ATPase subunits in the BRG/BRM
associated factor (BAF) complex that is recruited by transcription factors (TFs) to drive …
associated factor (BAF) complex that is recruited by transcription factors (TFs) to drive …
Transcriptomics analysis reveals molecular alterations underpinning spaceflight dermatology
Background Spaceflight poses a unique set of challenges to humans and the hostile
spaceflight environment can induce a wide range of increased health risks, including …
spaceflight environment can induce a wide range of increased health risks, including …
Lack of SMARCB1 expression characterizes a subset of human and murine peripheral T-cell lymphomas
A Fischer, TK Albert, N Moreno, M Interlandi… - Nature …, 2024 - nature.com
Peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS) is a heterogeneous group
of malignancies with poor outcome. Here, we identify a subgroup, PTCL-NOS SMARCB1 …
of malignancies with poor outcome. Here, we identify a subgroup, PTCL-NOS SMARCB1 …
Arid1a-dependent canonical BAF complex suppresses inflammatory programs to drive efficient Germinal Center B cell responses
A Abraham, D Samaniego-Castruita, I Han… - Nature …, 2024 - nature.com
Abstract The mammalian Brg1/Brm-associated factor (BAF) complexes are major regulators
of nucleosomal remodeling that are commonly mutated in several cancers, including …
of nucleosomal remodeling that are commonly mutated in several cancers, including …
IRF4 requires ARID1A to establish plasma cell identity in multiple myeloma
A Bolomsky, M Ceribelli, S Scheich, K Rinaldi… - Cancer Cell, 2024 - cell.com
Multiple myeloma (MM) is an incurable plasma cell malignancy that exploits transcriptional
networks driven by IRF4. We employ a multi-omics approach to discover IRF4 …
networks driven by IRF4. We employ a multi-omics approach to discover IRF4 …