The tumor suppressor prostate apoptosis response-4 (Par-4) has recently turned 'twenty-
five'. Beyond its indisputable role as an apoptosis inducer, an increasing and sometimes …

Hydrophobic cluster analysis (HCA) is an original approach for protein sequence analysis,
which provides access to the foldable repertoire of the protein universe, including yet …

It is recognized now that intrinsically disordered proteins (IDPs), which do not have unique
3D structures as a whole or in noticeable parts, constitute a significant fraction of any given …

The mammalian SPRY domain-and SOCS box-containing proteins, SPSB1 to SPSB4,
belong to the SOCS box family of E3 ubiquitin ligases. Substrate recognition sites for the …

The tumor suppressor protein prostate apoptosis response-4 (PAR-4) is silenced in a subset
of human cancers and its down-regulation serves as a mechanism for cancer cell survival …

Intrinsically disordered proteins play important roles in cell signaling, and dysregulation of
these proteins is associated with several diseases. Prostate apoptosis response-4 (Par-4) …

Par-4 is a unique proapoptotic protein with the ability to induce apoptosis selectively in
cancer cells. The X-ray crystal structure of the C-terminal domain of Par-4 (Par-4 CC), which …

Prostate apoptosis response-4 (Par-4) is a 38 kDa largely intrinsically disordered tumor
suppressor protein that functions in cancer cell apoptosis. Par-4 down-regulation is often …

Prostate apoptosis response-4 (Par-4) is a proapoptotic tumor suppressor protein that has
been linked to a large number of cancers. This 38 kilodalton (kDa) protein has been shown …

Abstract Prostate apoptosis response‐4 (Par‐4) tumor suppressor protein has gained
attention as a potential therapeutic target owing to its unique ability to selectively induce …