The S100B story: from biomarker to active factor in neural injury

F Michetti, N D'Ambrosi, A Toesca… - Journal of …, 2019 - Wiley Online Library
S100B is a Ca2+‐binding protein mainly concentrated in astrocytes. Its levels in biological
fluids (cerebrospinal fluid, peripheral and cord blood, urine, saliva, amniotic fluid) are …

S100: a multigenic family of calcium-modulated proteins of the EF-hand type with intracellular and extracellular functional roles

R Donato - The international journal of biochemistry & cell biology, 2001 - Elsevier
S100 is a multigenic family of non-ubiquitous Ca2+-modulated proteins of the EF-hand type
expressed in vertebrates exclusively and implicated in intracellular and extracellular …

Intracellular and extracellular roles of S100 proteins

R Donato - Microscopy research and technique, 2003 - Wiley Online Library
S100, a multigenic family of non‐ubiquitous Ca2+‐modulated proteins of the EF‐hand type
expressed in vertebrates exclusively, has been implicated in intracellular and extracellular …

S100B in brain damage and neurodegeneration

M Rothermundt, M Peters, JHM Prehn… - … research and technique, 2003 - Wiley Online Library
S100B is a calcium‐binding peptide produced mainly by astrocytes that exert paracrine and
autocrine effects on neurons and glia. Some knowledge has been acquired from in vitro and …

[HTML][HTML] Functional roles of S100 proteins, calcium-binding proteins of the EF-hand type

R Donato - Biochimica et Biophysica Acta (BBA)-Molecular Cell …, 1999 - Elsevier
A multigenic family of Ca2+-binding proteins of the EF-hand type known as S100 comprises
19 members that are differentially expressed in a large number of cell types. Members of this …

The S100B protein in biological fluids: more than a lifelong biomarker of brain distress

F Michetti, V Corvino, MC Geloso… - Journal of …, 2012 - Wiley Online Library
J. Neurochem.(2012) 120, 644–659. Abstract S100B is a calcium‐binding protein
concentrated in glial cells, although it has also been detected in definite extra‐neural cell …

S100B protein in biological fluids: a tool for perinatal medicine

F Michetti, D Gazzolo - Clinical Chemistry, 2002 - academic.oup.com
The diagnosis of perinatal insults currently relies on adequate documentation of general
medical and obstetric factors and on radiologic and laboratory assessments. The …

Growing role of S100B protein as a putative therapeutic target for neurological-and nonneurological-disorders

F Michetti, G Di Sante, ME Clementi… - Neuroscience & …, 2021 - Elsevier
S100B is a calcium-binding protein mainly expressed by astrocytes, but also localized in
other definite neural and extra-neural cell types. While its presence in biological fluids is …

S100 calcium binding proteins and ion channels

A Hermann, R Donato, TM Weiger… - Frontiers in …, 2012 - frontiersin.org
S100 Ca2+-binding proteins have been associated with a multitude of intracellular Ca2+-
dependent functions including regulation of the cell cycle, cell differentiation, cell motility and …

Molecular characterization of a third member of the guanylyl cyclase-activating protein subfamily

F Haeseleer, I Sokal, N Li, M Pettenati, N Rao… - Journal of Biological …, 1999 - ASBMB
The mammalian retina contains at least two guanylyl cyclases (GC1 and GC2) and two
guanylyl cyclase-activating proteins (GCAP1 and GCAP2). Here we present evidence of the …