B cells develop from hematopoietic precursor cells in an ordered maturation and selection
process. Extensive studies with many different mouse mutants provided fundamental …

Synthetic biology is bringing together engineers and biologists to design and build novel
biomolecular components, networks and pathways, and to use these constructs to rewire …

The American Academy of Allergy, Asthma & Immunology (AAAAI) and the American
College of Allergy, Asthma & Immunology (ACAAI) have jointly accepted responsibility for …

Can genetic and clinical findings made in a single patient be considered sufficient to
establish a causal relationship between genotype and phenotype? We report that up to 49 of …

B cells develop from hematopoietic stem cells in the bone marrow. Once generated, they
serve multiple roles in immune regulation and host defense. However, their most important …

Synthetic biology aims to create functional devices, systems and organisms with novel and
useful functions on the basis of catalogued and standardized biological building blocks …

Sophisticated genetic tools have made possible the identification of the genes responsible
for most well-described immunodeficiencies in the past 15 years. Mutations in Btk …

Interruptions or alterations in the B cell development pathway can lead to primary B cell
immunodeficiency with resultant absence or diminished immunoglobulin production. While …

Abnormalities in humoral immunity typically reflect a generalized or selective failure of
effective B-cell development. The developmental processes can be followed through …

Background: Patients with predominantly antibody deficiency (PAD) suffer from severe and
recurrent infections that require lifelong immunoglobulin replacement and prophylactic …