Over the past decade, the Sleeping Beauty (SB) transposon system has been developed as
the leading non-viral vector for gene therapy. This vector combines the advantages of …

Exercise benefits a variety of organ systems in mammals, and some of the best-recognized
effects of exercise on muscle are mediated by the transcriptional co-activator PPAR-γ co …

Investigational therapy can be successfully undertaken using viral-and nonviral-mediated ex
vivo gene transfer. Indeed, recent clinical trials have established the potential for genetically …

An important criterion for effective gene therapy is sufficient chromosomal integration activity.
The Sleeping Beauty (SB) transposon system is a plasmid system allowing efficient insertion …

Introduction: The continuous improvement of gene transfer technologies has broad
implications for stem cell biology, gene discovery, and gene therapy. Although viral vectors …

Sleeping Beauty (SB) transposons have been effective in delivering therapeutic genes to
treat certain diseases in mice. Hydrodynamic gene delivery of integrating transposons to 5 …

Hepatocellular carcinoma (HCC) is one of the most lethal cancers worldwide; however, the
genetic mechanisms underlying its pathogenesis are incompletely understood. Genetically …

Liver cancer is a complex multistep process requiring genetic alterations in multiple proto-
oncogenes and tumor suppressor genes. Although hundreds of genes are known to play …

DNA transposon-based gene delivery vectors represent a promising new branch of
randomly integrating vector development for gene therapy. For the side-by-side evaluation …

Primary liver cancer is an increasing problem worldwide and is associated with significant
mortality. A popular method of modeling liver cancer in mice is plasmid hydrodynamic tail …