Exceptional advances in molecular biology and genetic research have expedited cancer
drug development tremendously. The declared paradigm is the development …

Hsp90 is an ATP dependent molecular chaperone protein which integrates multiple
oncogenic pathways. As such, Hsp90 inhibition is a promising anti-cancer strategy. Several …

Twenty-five years ago the first small molecule inhibitors of Hsp90 were identified. In the
intervening years there has been dramatic progress in basic scientific understanding of the …

Osteosarcoma is the most common malignant primary bone tumor in children and
adolescents. Current optimal treatment for osteosarcoma consists of multi-agent …

Heat shock protein 90 has emerged as an important target in several diseases. The present
review will discuss our understanding of the role played by Hsp90 in regulating and …

Hsp90 is a ubiquitous chaperone with important roles in the organization and maturation of
client proteins that are involved in the progression and survival of cancer cells. Multiple …

Heat shock protein 90 (Hsp90) is a molecular chaperone required for the stability and
function of several conditionally activated and/or expressed signaling proteins as well as …

Purpose: Activation of the mitogen-activated protein kinase (MAPK) pathway and the
phosphatidylinositol 3-kinase/AKT pathway seems to be critical for melanoma proliferation …

Purpose Natural killer (NK) cell cytotoxicity correlates with the ligation of activating receptors
(eg, NKG2D) by their ligands (eg, MHC class I–related chains [MIC] A and B) on target cells …

In tumours, hypoxia—a condition in which the demand for oxygen is higher than its
availability—is well known to be associated with reduced sensitivity to radiotherapy and …