A large body of evidence has emerged in the past decade supporting a role for the gut
microbiome in the regulation of blood pressure. The field has moved from association to …

Dr Irvine Page proposed the Mosaic Theory of Hypertension in the 1940s advocating that
hypertension is the result of many factors that interact to raise blood pressure and cause end …

The renin-angiotensin-aldosterone system plays crucial roles in cardiovascular physiology
and pathophysiology. However, many of the signaling mechanisms have been unclear. The …

Hypertension affects 30% of adults and is the leading risk factor for heart attack and stroke.
Traditionally, hypertension has been regarded as a disorder of two systems that are involved …

Elevated cardiovascular risk including stroke, heart failure, and heart attack is present even
after normalization of blood pressure in patients with hypertension. Underlying immune cell …

Background: High blood pressure (BP) continues to be a major, poorly controlled but
modifiable risk factor for cardiovascular death. Among key Western lifestyle factors, a diet …

High blood pressure is present in more than one billion adults worldwide and is the most
important modifiable risk factor of death resulting from cardiovascular disease. While many …

Aims Renal inflammation, leading to fibrosis and impaired function is a major contributor to
the development of hypertension. The NLRP3 inflammasome mediates inflammation in …

The teleology of sex differences has been argued since at least as early as Aristotle's
controversial Generation of Animals more than 300 years BC, which reflects the sex bias of …

Hypertension is a global public health issue and the leading cause of premature death in
humans. Despite more than a century of research, hypertension remains difficult to cure due …