Beyond fuelling cellular activities with building blocks and energy, metabolism also
integrates environmental conditions into intracellular signals. The underlying regulatory …

Quantitative empirical relationships between cell composition and growth rate played an
important role in the early days of microbiology. Gradually, the focus of the field began to …

In bacteria, the rate of cell proliferation and the level of gene expression are intimately
intertwined. Elucidating these relations is important both for understanding the physiological …

A central aim of cell biology was to understand the strategy of gene expression in response
to the environment. Here, we study gene expression response to metabolic challenges in …

Growth experiments are routinely used to analyze basic properties of a given organism or
cellular model. Similarly, within the TRANSLUCENT project the characterization of cellular …

High-quality, well-annotated genome sequences and standardized laboratory strains fuel
experimental and evolutionary research. We present improved genome sequences of three …

Functional genomic strategies have become fundamental for annotating gene function and
regulatory networks. Here, we combined functional genomics with proteomics by quantifying …

A significant obstacle in training predictive cell models is the lack of integrated data sources.
We develop semi-supervised normalization pipelines and perform experimental …

Adaptive evolution is generally assumed to progress through the accumulation of beneficial
mutations. However, as deleterious mutations are common in natural populations, they …

Drug resistance is a common cause of treatment failure for HIV infection and cancer. The
high mutation rate of HIV leads to genetic heterogeneity among viral populations and …