Lung cancer is the leading cause of cancer-related mortality worldwide. Advances in our
understanding of the genomics of lung cancer have led to substantial progress in the …

Lung, breast, colorectal, and prostate cancers are the most incident worldwide. Optimal
population-based cancer screening methods remain an unmet need, since cancer detection …

This article reviews the mechanisms of gene silencing in cancer and clinical applications of
this phenomenon. The silencing of genes, especially tumor-suppressor genes, is a key …

Advances in genomics, proteomics and molecular pathology have generated many
candidate biomarkers with potential clinical value. Their use for cancer staging and …

The past few years have seen an explosion of interest in the epigenetics of cancer. This has
been a consequence of both the exciting coalescence of the chromatin and DNA …

DNA methylation is an important regulator of gene transcription, and its role in
carcinogenesis has been a topic of considerable interest in the last few years. Alterations in …

It has been known for decades that it is possible to detect small amounts of extracellular
nucleic acids in plasma and serum of healthy and diseased human beings. The unequivocal …

In lung adenocarcinoma, oncogenic EGFR mutations co-occur with many tumor suppressor
gene alterations; however, the extent to which these contribute to tumor growth and …

Lung cancer is the leading cause of cancer death worldwide, and adenocarcinoma is its
most common histological subtype. Clinical and molecular evidence indicates that lung …

Growing cancer incidence and mortality worldwide demands development of accurate
biomarkers to perfect detection, diagnosis, prognostication and monitoring. Urologic …