Cardiovascular disease is the leading cause of death worldwide. New therapeutic strategies
are aimed to modulate the athero-inflammatory process that partially orchestrates underlying …

Observational studies have associated the increase in fibroblast growth factor (FGF) 23
levels, the main regulator of phosphate levels, with the onset of diabetes. These studies …

Cellular stress can lead to the production of reactive oxygen species (ROS) while
autophagy, as a catabolic pathway, protects the cells against stress. Autophagy in its turn …

Background Longevity gene klotho (KL) is associated with age-related phenotypes but has
not been evaluated against a direct human biomarker of cellular aging. We examined KL …

Klotho, which is a life extension factor, and erythropoietin (EPO) have been introduced as
effective neuroprotective factors in several neurological disorders. The present study is an …

Chronic kidney disease (CKD) has been associated with a higher risk of cardiovascular
disease (CVD). CKD patients present a decrease in the levels of the protein Klotho that …

Introduction Klotho protein is predominantly expressed in the kidneys and has also been
detected in vascular tissue and peripheral blood circulating cells to a lesser extent. Carotid …

Background: The longevity gene Klotho (KL) was recently associated with
neurodegenerative diseases including Alzheimer's disease (AD). Its role in the brain has not …

Background Diabetic kidney disease (DKD) is associated with a higher risk of
cardiovascular disease (CVD). Pentoxifylline (PTF), a nonselective phosphodiesterase …

ندــب یاه هاگتــسد رتــشيب رــب یدــيفم تارــثا یرــيپ دــض ريــسکا کــی ناوــنع هب یوــتولک:
هــمدقم زا یرايــسب رد وــتولک دــيفم تارــثا رــب یــنبم یداــیز تاــشرازگ رــيخا هــهد ود رد. دراد …‎