Mitochondria are key regulators of cell fate during disease. They control cell survival via the
production of ATP that fuels cellular processes and, conversely, cell death via the induction …

Mitochondria fulfill numerous cellular functions including ATP production, Ca2+ buffering,
neurotransmitter synthesis and degradation, ROS production and sequestration, apoptosis …

Ischemic stroke is a severe cerebrovascular disease with high mortality and morbidity. In
recent years, reperfusion treatments based on thrombolytic and thrombectomy are major …

Ischemic stroke is one of the leading causes of death and also a major cause of adult
disability worldwide. Revascularization via reperfusion therapy is currently a standard …

Low oxygen availability, a condition known as hypoxia, is a common feature of various
pathologies including stroke, ischemic heart disease, and cancer. Hypoxia adaptation …

Cerebral ischemia results in a poor oxygen supply and cerebral infarction. Reperfusion to
the ischemic area is the best therapeutic approach. Although reperfusion after ischemia has …

Mitochondria are important for providing cellular energy ATP through the oxidative
phosphorylation pathway. They are also critical in regulating many cellular functions …

Mitochondria are double membrane organelles within eukaryotic cells, which act as cellular
power houses, depending on the continuous availability of oxygen. Nevertheless, under …

The current standard of care for acute myocardial infarction or 'heart attack'is timely
restoration of blood flow to the ischemic region of the heart. While reperfusion is essential for …

Global brain ischemia/reperfusion induces neuronal damage in vulnerable brain regions,
leading to mitochondrial dysfunction and subsequent neuronal death. Induction of neuronal …