Specific IL-1 family cytokines are expressed by cells as cytosolic pro-forms that require
cleavage for their activity and cellular release. IL-1β, IL-18, and IL-37 maturation and …

Inflammation is an important component of the tumor microenvironment. IL‐1 is an
inflammatory cytokine which plays a key role in carcinogenesis and tumor progression. IL‐1 …

The extracellular forms of the IL‐1 cytokines are active through binding to specific receptors
on the surface of target cells. IL‐1 ligands bind to the extracellular portion of their ligand …

Psoriasis is a chronic systemic inflammatory disease causing erythematosus and scaly skin
plaques; up to 30% of patients with psoriasis develop Psoriatic Arthritis (PsA), which is …

Despite advances in the diagnostic and therapeutic modalities, the prognosis of several
solid tumor malignancies remains poor. Different factors associated with solid tumors …

Several new discoveries have revived interest in the pathogenic potential and possible
clinical roles of IL-18. IL-18 is an IL-1 family cytokine with potent ability to induce IFNγ …

The plasma membrane tetraspan molecule MS4A4A is selectively expressed by
macrophage-lineage cells, but its function is unknown. Here we report that MS4A4A was …

Simple Summary Recent years marked the discovery and increased understanding of the
role immune checkpoints play in immunity against cancer. This has revolutionized cancer …

The interleukin (IL)-1 family of cytokines is composed of 11 members, including the most
recently discovered IL-36α, β, γ, IL-37, and IL-38. Similar to IL-1, IL-36 cytokines are initiators …

Cytokine storms are crucial in the development of various inflammatory diseases, including
sepsis and autoimmune disorders. The immunosuppressive cytokine INTERLEUKIN (IL)-37 …