[HTML][HTML] Single-cell spatial multi-omics and deep learning dissect enhancer-driven gene regulatory networks in liver zonation
C Bravo Gonzalez-Blas, I Matetovici, H Hillen… - Nature Cell …, 2024 - nature.com
In the mammalian liver, hepatocytes exhibit diverse metabolic and functional profiles based
on their location within the liver lobule. However, it is unclear whether this spatial variation …
on their location within the liver lobule. However, it is unclear whether this spatial variation …
Enhancer grammar of liver cell types and hepatocyte zonation states
Cell type identity is encoded by gene regulatory networks (GRN), in which transcription
factors (TFs) bind to enhancers to regulate target gene expression. In the mammalian liver …
factors (TFs) bind to enhancers to regulate target gene expression. In the mammalian liver …