Diabetic retinopathy: vascular and inflammatory disease

F Semeraro, A Cancarini, R dell'Omo… - Journal of diabetes …, 2015 - Wiley Online Library
Diabetic retinopathy (DR) is the leading cause of visual impairment in the working‐age
population of the Western world. The pathogenesis of DR is complex and several vascular …

Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis

D Hanahan, J Folkman - cell, 1996 - cell.com
Introduction confirmed this result and further revealed that in the Blood vessels are
fundamentally composed of endotheabsence of access to an adequate vasculature, tumor …

Mechanisms of angiogenesis

W Risau - Nature, 1997 - nature.com
After the developing embryo has formed a primary vascular plexus by a process termed
vasculogenesis, further blood vessels are generated by both sprouting and non-sprouting …

Tumorigenesis and the angiogenic switch

G Bergers, LE Benjamin - Nature reviews cancer, 2003 - nature.com
It has become evident that we cannot understand tumour growth without considering
components of the stromal microenvironment, such as the vasculature. At the same time, the …

Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1

JA Forsythe, BH Jiang, NV Iyer, F Agani… - … and cellular biology, 1996 - Taylor & Francis
Expression of vascular endothelial growth factor (VEGF) is induced in cells exposed to
hypoxia or ischemia. Neovascularization stimulated by VEGF occurs in several important …

The biology of vascular endothelial growth factor

N Ferrara, T Davis-Smyth - Endocrine reviews, 1997 - academic.oup.com
Biology of Vascular Endothelial Growth Factor | Endocrine Reviews | Oxford Academic Skip to
Main Content Advertisement Oxford Academic Journals Books Search Menu Information …

Vascular endothelial growth factor (VEGF) and its receptors

G Neufeld, T Cohen, S Gengrinovitch… - The FASEB …, 1999 - Wiley Online Library
Vascular endothelial growth factor (VEGF) is a highly specific mitogen for vascular
endothelial cells. Five VEGF isoforms are generated as a result of alternative splicing from a …

Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1α

NV Iyer, LE Kotch, F Agani, SW Leung… - Genes & …, 1998 - genesdev.cshlp.org
Hypoxia is an essential developmental and physiological stimulus that plays a key role in
the pathophysiology of cancer, heart attack, stroke, and other major causes of mortality …

Hypoxia response elements in the aldolase A, enolase 1, and lactate dehydrogenase A gene promoters contain essential binding sites for hypoxia-inducible factor 1

GL Semenza, BH Jiang, SW Leung… - Journal of Biological …, 1996 - ASBMB
Hypoxia-inducible factor 1 (HIF-1) is a basic helix-loop-helix transcription factor which is
expressed when mammalian cells are subjected to hypoxia and which activates …

The role of vascular endothelial growth factor in wound healing

P Bao, A Kodra, M Tomic-Canic, MS Golinko… - Journal of Surgical …, 2009 - Elsevier
BACKGROUND: A chronic wound is tissue with an impaired ability to heal. This is often a
consequence of one of the following etiologies: diabetes, venous reflux, arterial insufficiency …