Parietal cells are responsible for gastric acid secretion, which aids in the digestion of food,
absorption of minerals, and control of harmful bacteria. However, a fine balance of activators …

Calcium is an essential trace element and a vital contributor to numerous reactions in
virtually every human cell. To ensure normal physiologic functions, intracellular and …

The cloning of a G protein-coupled extracellular Ca2+ (Cao 2+)-sensing receptor (CaR) has
elucidated the molecular basis for many of the previously recognized effects of Cao 2+ on …

The extracellular calcium (Ca2+ o)-sensing receptor (CaR) recognizes and responds to
(ie,“senses”) Ca2+ o as its principal physiological ligand. In the present studies, we …

Calcium balance is essential for a multitude of physiological processes, ranging from cell
signaling to maintenance of bone health. Adequate intestinal absorption of calcium is a …

The calcium-sensing receptor (CaSR) plays a pivotal role in systemic calcium metabolism by
regulating parathyroid hormone secretion and urinary calcium excretion. The CaSR is …

The extracellular calcium ion (Ca2+ e)-sensing receptor (CaR) enables key tissues that
maintain Ca2+ e homeostasis to sense changes in the Ca2+ e concentration. These tissues …

The extracellular calcium-sensing receptor (CaR; alternate gene names, CaR or Casr) is a
membrane-spanning G protein–coupled receptor. CaR is highly expressed in the …

The calcium-sensing receptor (CaR) is the major sensor and regulator of extracellular Ca2+,
whose activity is allosterically regulated by amino acids and pH. Recently, CaR has been …

The calcium-sensing receptor (CaSR) has played an important role as a target in the
treatment of a variety of disease states over the past 20 plus years. In this review, we give an …