The physiology of the gastric parietal cell
AC Engevik, I Kaji, JR Goldenring - Physiological reviews, 2020 - journals.physiology.org
Parietal cells are responsible for gastric acid secretion, which aids in the digestion of food,
absorption of minerals, and control of harmful bacteria. However, a fine balance of activators …
absorption of minerals, and control of harmful bacteria. However, a fine balance of activators …
Physiology of calcium homeostasis: an overview
N Matikainen, T Pekkarinen… - Endocrinology and …, 2021 - endo.theclinics.com
Calcium is an essential trace element and a vital contributor to numerous reactions in
virtually every human cell. To ensure normal physiologic functions, intracellular and …
virtually every human cell. To ensure normal physiologic functions, intracellular and …
Extracellular calcium sensing and extracellular calcium signaling
EM Brown, RJ MacLeod - Physiological reviews, 2001 - journals.physiology.org
The cloning of a G protein-coupled extracellular Ca2+ (Cao 2+)-sensing receptor (CaR) has
elucidated the molecular basis for many of the previously recognized effects of Cao 2+ on …
elucidated the molecular basis for many of the previously recognized effects of Cao 2+ on …
l-Amino acid sensing by the extracellular Ca2+-sensing receptor
AD Conigrave, SJ Quinn… - Proceedings of the …, 2000 - National Acad Sciences
The extracellular calcium (Ca2+ o)-sensing receptor (CaR) recognizes and responds to
(ie,“senses”) Ca2+ o as its principal physiological ligand. In the present studies, we …
(ie,“senses”) Ca2+ o as its principal physiological ligand. In the present studies, we …
Gastric acid, calcium absorption, and their impact on bone health
S Kopic, JP Geibel - Physiological reviews, 2013 - journals.physiology.org
Calcium balance is essential for a multitude of physiological processes, ranging from cell
signaling to maintenance of bone health. Adequate intestinal absorption of calcium is a …
signaling to maintenance of bone health. Adequate intestinal absorption of calcium is a …
[HTML][HTML] The calcium-sensing receptor and the hallmarks of cancer
The calcium-sensing receptor (CaSR) plays a pivotal role in systemic calcium metabolism by
regulating parathyroid hormone secretion and urinary calcium excretion. The CaSR is …
regulating parathyroid hormone secretion and urinary calcium excretion. The CaSR is …
Clinical lessons from the calcium-sensing receptor
EM Brown - Nature Clinical Practice Endocrinology & Metabolism, 2007 - nature.com
The extracellular calcium ion (Ca2+ e)-sensing receptor (CaR) enables key tissues that
maintain Ca2+ e homeostasis to sense changes in the Ca2+ e concentration. These tissues …
maintain Ca2+ e homeostasis to sense changes in the Ca2+ e concentration. These tissues …
The calcium-sensing receptor is required for normal calcium homeostasis independent of parathyroid hormone
CH Kos, AC Karaplis, JB Peng… - The Journal of …, 2003 - Am Soc Clin Investig
The extracellular calcium-sensing receptor (CaR; alternate gene names, CaR or Casr) is a
membrane-spanning G protein–coupled receptor. CaR is highly expressed in the …
membrane-spanning G protein–coupled receptor. CaR is highly expressed in the …
Calcium-sensing receptor is a physiologic multimodal chemosensor regulating gastric G-cell growth and gastrin secretion
J Feng, CD Petersen, DH Coy… - Proceedings of the …, 2010 - National Acad Sciences
The calcium-sensing receptor (CaR) is the major sensor and regulator of extracellular Ca2+,
whose activity is allosterically regulated by amino acids and pH. Recently, CaR has been …
whose activity is allosterically regulated by amino acids and pH. Recently, CaR has been …
Calcium-sensing receptor 20 years later
TI Alfadda, AMA Saleh, P Houillier… - American Journal of …, 2014 - journals.physiology.org
The calcium-sensing receptor (CaSR) has played an important role as a target in the
treatment of a variety of disease states over the past 20 plus years. In this review, we give an …
treatment of a variety of disease states over the past 20 plus years. In this review, we give an …