Human Vγ9/Vδ2 T cells play a crucial role in the immune response to microbial pathogens,
yet their unconventional reactivity towards non-peptide antigens has been enigmatic until …

Various non-peptidic ligands which specifically activate most of circulating human Vγ9/Vδ2 T
lymphocytes are now known. Most of these are so-called phosphoantigens and directly …

Gamma/delta (γδ) T cells are innate-like immune effectors that are a critical component
linking innate and adaptive immune responses. They are recognized for their contribution to …

We present a comprehensive account on our efforts behind the recently published synthesis
of waixenicin A. Our approach for constructing the dihydropyran ring relied on an …

The [4Fe–4S] protein IspH in the methylerythritol phosphate isoprenoid biosynthesis
pathway is an important anti-infective drug target, but its mechanism of action is still the …

The nonmevalonate isoprenoid pathway is an established target for antiinfective drug
development. This paper describes high-throughput methods for the screening of 2 C-methyl …

In this study, a cDNA microarray was developed from over 60,000 mRNA readings to
analyze the expression profiles of transcriptomes of Haematococcus lacustris under …

The immunological characterization of (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate
(HMB-PP), and its methylenediphosphonate analogue, HMB-PCP, is described. With an …

The late‐stage functionalization of indole‐and tryptophan‐containing compounds with
reactive moieties facilitates downstream diversification and leads to changes in their …

Isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) serve as the
universal precursors for the biosynthesis of terpenes. Besides the well-known mevalonate …