Cholesterol homeostasis is essential in normal physiology of all cells. One of several
proteins involved in cholesterol homeostasis is the ATP-binding cassette transporter A1 …

Adenosine triphosphate (ATP)-binding cassette (ABC) transporters are a 48-member
superfamily of membrane proteins that actively transport a variety of biological substrates …

Here we present a draft genome sequence of the common chimpanzee (Pan troglodytes).
Through comparison with the human genome, we have generated a largely complete …

Specialized functions of macrophages have evolved to protect the body from infection.
However, the same mechanisms that enable phagocytosis of pathogens and activation of …

HDLs protect against the development of atherosclerosis, but the underlying mechanisms
are poorly understood. HDL and its apolipoproteins can promote cholesterol efflux from …

Background: The prevalence of duodenal carcinoma is much higher in familial
adenomatous polyposis (FAP) than in the background population, and duodenal …

A hallmark of atherosclerotic cardiovascular disease (CVD) is the accumulation of
cholesterol in arterial macrophages. Factors that modulate circulating and tissue cholesterol …

The efficacy of drug therapy results from the complex interplay of multiple processes that
govern drug disposition and response. Most studies to date have focused on the contribution …

ABCA1 (ATP-binding cassette transporter A1) is a major regulator of cholesterol efflux and
high density lipoprotein (HDL) metabolism. Mutations in human ABCA1 cause severe HDL …

The prevention and treatment of cardiovascular diseases (CVD) has largely focused on
lowering circulating LDL cholesterol, yet a significant burden of atherosclerotic disease …