The potential of siRNA based drug delivery in respiratory disorders: Recent advances and progress

K Dua, R Wadhwa, G Singhvi, V Rapalli… - Drug development …, 2019 - Wiley Online Library
Lung diseases are the leading cause of mortality worldwide. The currently available
therapies are not sufficient, leading to the urgent need for new therapies with sustained anti …

A new dawn for eosinophils in the tumour microenvironment

S Grisaru-Tal, M Itan, AD Klion, A Munitz - Nature Reviews Cancer, 2020 - nature.com
Eosinophils are evolutionarily conserved, pleotropic cells that display key effector functions
in allergic diseases, such as asthma. Nonetheless, eosinophils infiltrate multiple tumours …

Markers of inflammation

DR Germolec, KA Shipkowski, RP Frawley… - … testing: Methods and …, 2018 - Springer
Inflammation is a complex and necessary component of the response to biological,
chemical, or physical stimuli, and the cellular and molecular events that initiate and regulate …

Eosinophils from A to Z

L Gigon, T Fettrelet, S Yousefi, D Simon, HU Simon - Allergy, 2023 - Wiley Online Library
Eosinophils are bone marrow‐derived granulocytes and are found in low numbers in the
peripheral blood of healthy subjects. In type 2 inflammatory diseases, eosinopoiesis in the …

Eosinophil knockout humans: uncovering the role of eosinophils through eosinophil-directed biological therapies

EA Jacobsen, DJ Jackson, E Heffler… - Annual review of …, 2021 - annualreviews.org
The enigmatic eosinophil has emerged as an exciting component of the immune system,
involved in a plethora of homeostatic and inflammatory responses. Substantial progress has …

T-helper type 2–driven inflammation defines major subphenotypes of asthma

PG Woodruff, B Modrek, DF Choy, G Jia… - American journal of …, 2009 - atsjournals.org
Rationale: T-helper type 2 (Th2) inflammation, mediated by IL-4, IL-5, and IL-13, is
considered the central molecular mechanism underlying asthma, and Th2 cytokines are …

The eosinophil

ME Rothenberg, SP Hogan - Annu. Rev. Immunol., 2006 - annualreviews.org
Eosinophils have been considered end-stage cells involved in host protection against
parasites. However, numerous lines of evidence have now changed this perspective by …

Adjuvant System AS03 containing α-tocopherol modulates innate immune response and leads to improved adaptive immunity

S Morel, A Didierlaurent, P Bourguignon, S Delhaye… - Vaccine, 2011 - Elsevier
AS03 is an Adjuvant System (AS) containing α-tocopherol and squalene in an oil-in-water
(o/w) emulsion. AS03 has been considered for the development of pandemic and seasonal …

Eosinophils: biological properties and role in health and disease

SP Hogan, HF Rosenberg, R Moqbel… - Clinical & …, 2008 - Wiley Online Library
Eosinophils are pleiotropic multifunctional leukocytes involved in initiation and propagation
of diverse inflammatory responses, as well as modulators of innate and adaptive immunity …

Celastrol: a spectrum of treatment opportunities in chronic diseases

R Cascão, JE Fonseca, LF Moita - Frontiers in medicine, 2017 - frontiersin.org
The identification of new bioactive compounds derived from medicinal plants with significant
therapeutic properties has attracted considerable interest in recent years. Such is the case of …