The potential of siRNA based drug delivery in respiratory disorders: Recent advances and progress
Lung diseases are the leading cause of mortality worldwide. The currently available
therapies are not sufficient, leading to the urgent need for new therapies with sustained anti …
therapies are not sufficient, leading to the urgent need for new therapies with sustained anti …
A new dawn for eosinophils in the tumour microenvironment
Eosinophils are evolutionarily conserved, pleotropic cells that display key effector functions
in allergic diseases, such as asthma. Nonetheless, eosinophils infiltrate multiple tumours …
in allergic diseases, such as asthma. Nonetheless, eosinophils infiltrate multiple tumours …
Markers of inflammation
DR Germolec, KA Shipkowski, RP Frawley… - … testing: Methods and …, 2018 - Springer
Inflammation is a complex and necessary component of the response to biological,
chemical, or physical stimuli, and the cellular and molecular events that initiate and regulate …
chemical, or physical stimuli, and the cellular and molecular events that initiate and regulate …
Eosinophils from A to Z
L Gigon, T Fettrelet, S Yousefi, D Simon, HU Simon - Allergy, 2023 - Wiley Online Library
Eosinophils are bone marrow‐derived granulocytes and are found in low numbers in the
peripheral blood of healthy subjects. In type 2 inflammatory diseases, eosinopoiesis in the …
peripheral blood of healthy subjects. In type 2 inflammatory diseases, eosinopoiesis in the …
Eosinophil knockout humans: uncovering the role of eosinophils through eosinophil-directed biological therapies
The enigmatic eosinophil has emerged as an exciting component of the immune system,
involved in a plethora of homeostatic and inflammatory responses. Substantial progress has …
involved in a plethora of homeostatic and inflammatory responses. Substantial progress has …
T-helper type 2–driven inflammation defines major subphenotypes of asthma
PG Woodruff, B Modrek, DF Choy, G Jia… - American journal of …, 2009 - atsjournals.org
Rationale: T-helper type 2 (Th2) inflammation, mediated by IL-4, IL-5, and IL-13, is
considered the central molecular mechanism underlying asthma, and Th2 cytokines are …
considered the central molecular mechanism underlying asthma, and Th2 cytokines are …
The eosinophil
ME Rothenberg, SP Hogan - Annu. Rev. Immunol., 2006 - annualreviews.org
Eosinophils have been considered end-stage cells involved in host protection against
parasites. However, numerous lines of evidence have now changed this perspective by …
parasites. However, numerous lines of evidence have now changed this perspective by …
Adjuvant System AS03 containing α-tocopherol modulates innate immune response and leads to improved adaptive immunity
S Morel, A Didierlaurent, P Bourguignon, S Delhaye… - Vaccine, 2011 - Elsevier
AS03 is an Adjuvant System (AS) containing α-tocopherol and squalene in an oil-in-water
(o/w) emulsion. AS03 has been considered for the development of pandemic and seasonal …
(o/w) emulsion. AS03 has been considered for the development of pandemic and seasonal …
Eosinophils: biological properties and role in health and disease
SP Hogan, HF Rosenberg, R Moqbel… - Clinical & …, 2008 - Wiley Online Library
Eosinophils are pleiotropic multifunctional leukocytes involved in initiation and propagation
of diverse inflammatory responses, as well as modulators of innate and adaptive immunity …
of diverse inflammatory responses, as well as modulators of innate and adaptive immunity …
Celastrol: a spectrum of treatment opportunities in chronic diseases
The identification of new bioactive compounds derived from medicinal plants with significant
therapeutic properties has attracted considerable interest in recent years. Such is the case of …
therapeutic properties has attracted considerable interest in recent years. Such is the case of …