Triblock copolymeric drug delivery as an emerging nanocarrier for treatment of infectious diseases

V Singh, K Eljaaly, S Md, NA Alhakamy… - Journal of Drug Delivery …, 2022 - Elsevier
Polymers have long been employed as carriers of choice for efficient delivery of therapeutic
agents. Several block copolymers including triblock copolymers have been designed using …

Triblock copolymers for nano-sized drug delivery systems

NH Hoang, C Lim, T Sim, KT Oh - Journal of Pharmaceutical Investigation, 2017 - Springer
Triblock copolymers have been widely used as a material for developing drug delivery
systems (DDS). In terms of architecture, triblock copolymers could be classified into …

RNA-Seq-guided triple-combination nano-system of gold nanocluster, quercetin, and docetaxel for ultimate synergistic photothermal-chemotherapy against MDR …

Y Shin, M Kim, ES Lee, C Lim, KT Oh - Nano Today, 2023 - Elsevier
For oncological purposes, hyperthermia has increasingly emerged as a good therapeutic
option for patients without fitness to undergo surgery, or for those with surgically …

A feasibility study of a pH sensitive nanomedicine using doxorubicin loaded poly (aspartic acid-graft-imidazole)-block-poly (ethylene glycol) micelles

ES Lee, JH Kim, T Sim, YS Youn, BJ Lee… - Journal of Materials …, 2014 - pubs.rsc.org
A polyelectrolyte block copolymer, poly (aspartic acid-graft-imidazole)-block-poly (ethylene
glycol)(P (Asp-g-Im)-PEG), with several advantages such as an easy synthesis, having a …

Development of a new tri-block copolymer with a functional end and its feasibility for treatment of metastatic breast cancer

HT Song, NH Hoang, JM Yun, YJ Park, EH Song… - Colloids and Surfaces B …, 2016 - Elsevier
We have developed nanomedicine vehicle based on a biocompatible tri-block copolymer,
poly (ethylene glycol)-block-poly (lactic acid)-block-poly (ethylene glycol)(PEG-PLA-PEG) by …

Development of a robust pH-sensitive polyelectrolyte ionomer complex for anticancer nanocarriers

C Lim, YS Youn, KS Lee, NH Hoang, T Sim… - International Journal …, 2016 - Taylor & Francis
A polyelectrolyte ionomer complex (PIC) composed of cationic and anionic polymers was
developed for nanomedical applications. Here, a poly (ethylene glycol)–poly (lactic acid) …

Cyclic RGD-conjugated Pluronic® blending system for active, targeted drug delivery

C Lim, J Moon, T Sim, NH Hoang, WR Won… - International Journal …, 2018 - Taylor & Francis
Background Blending micellar systems of different types of polymers has been proposed as
an efficient approach for tailor-made drug formulations. The lamellar structure of …

PEG-coumarin based biocompatible self-assembled fluorescent nanoaggregates synthesized via click reactions and studies of aggregation behavior

G Behl, M Sikka, A Chhikara, M Chopra - Journal of colloid and interface …, 2014 - Elsevier
Hypothesis Click chemistry has found wide application in drug discovery, bioconjugation
reactions, polymer chemistry and synthesis of amphiphilic materials with pharmaceutical …

An on-demand pH-sensitive nanocluster for cancer treatment by combining photothermal therapy and chemotherapy

T Sim, C Lim, NH Hoang, Y Shin, JC Kim, JY Park… - Pharmaceutics, 2020 - mdpi.com
Combination therapy is considered to be a promising strategy for improving the therapeutic
efficiency of cancer treatment. In this study, an on-demand pH-sensitive nanocluster (NC) …

Characterization of a triblock copolymer, poly (ethylene glycol)-polylactide-poly (ethylene glycol), with different structures for anticancer drug delivery applications

NH Hoang, C Lim, T Sim, ES Lee, YS Youn, D Kim… - Polymer Bulletin, 2017 - Springer
Abstract Formulation optimization from the early steps plays an important role in the success
of drug delivery system development. To optimize nano-sized micelles based on poly …