Enhanced Solubility and Bioavailability of Dolutegravir by Solid Dispersion Method: In Vitro and In Vivo Evaluation—a Potential Approach for HIV Therapy
Being a candidate of BCS class II, dolutegravir (DTG), a recently approved antiretroviral
drug, possesses solubility issues. The current research was aimed to improve the solubility …
drug, possesses solubility issues. The current research was aimed to improve the solubility …
A promising approach to design thermosensitive in situ gel based on solid dispersions of desloratadine with Kolliphor® 188 and Pluronic® F127
G Yurtdaş-Kırımlıoğlu - Journal of Thermal Analysis and Calorimetry, 2022 - Springer
Desloratadine (DSL) is an anti-allergic agent but its efficacy is limited with its low dissolution
rate and aqueous solubility results in restricted bioavailability. The current study examines …
rate and aqueous solubility results in restricted bioavailability. The current study examines …
Physicochemical reports of gliclazide-carplex solid dispersions and tablets prepared with directly compressible co-processed excipients
S Paul, KF Asha, IZ Alam, MA Ali, ME Al-Mamun… - Heliyon, 2023 - cell.com
Objectives The main goal of this research was to develop better tablet formulations by
utilizing solid dispersions (SDs) and coprocessing excipients composite to achieve a better …
utilizing solid dispersions (SDs) and coprocessing excipients composite to achieve a better …
Development of the Binary and Ternary Atorvastatin Solid Dispersions: In Vitro and In Vivo Investigations
E Faraji, M Mohammadi… - BioMed Research …, 2021 - Wiley Online Library
The object of this study was to prepare binary and ternary solid dispersions of atorvastatin
(ATR) by the melting method using PEGs and poloxamer 188 (P188) as the carriers, singly …
(ATR) by the melting method using PEGs and poloxamer 188 (P188) as the carriers, singly …
Formulation of silymarin binary and ternary solid dispersions: Characterization, simulation study and cell viability assessment against lung cancer cell line
FA Alkathiri, SI Bukhari, SS Imam, S Alshehri… - Heliyon, 2024 - cell.com
Silymarin (SL) is a water-insoluble flavonoid used in the treatment of different diseases, but
its therapeutic activity is limited due to its low solubility. So, in the present study, SL solid …
its therapeutic activity is limited due to its low solubility. So, in the present study, SL solid …
Development and characterization of lyophilized cefpodoxime proxetil-Pluronic® F127/polyvinylpyrrolidone K30 solid dispersions with improved dissolution and …
G Yurtdaş-Kırımlıoğlu - Pharmaceutical Development and …, 2021 - Taylor & Francis
The aim of this study was the development of hard-cellulose capsules containing
cefpodoxime proxetil (CEF)(BCS Class II) loaded novel Pluronic® F127 (P127) …
cefpodoxime proxetil (CEF)(BCS Class II) loaded novel Pluronic® F127 (P127) …
[PDF][PDF] Enhancement of aqueous solubility and dissolution rate of etoricoxib by solid dispersion technique
MM AlKhalidi, FJ Jawad - Iraqi Journal of Pharmaceutical Sciences (P-ISSN …, 2020 - iasj.net
Etoricoxib (EXB) is a highly selective cox-2 inhibitor which belongs to the non-steroidal
antiinflammatory drug (NSAID). EXB is a class II drug according to the biopharmaceutical …
antiinflammatory drug (NSAID). EXB is a class II drug according to the biopharmaceutical …
Development and Optimization of Cefuroxime Axetil Nanosuspension for Improved Oral Bioavailability: In-Vitro and In-Vivo Investigations
H Mishra, A Behera, SS Kar, S Dash, S Moharana… - BioNanoScience, 2023 - Springer
Cefuroxime axetil is a significantly used in drug formulation. Therefore, this study aimed to
prepare a nanosuspension of cefuroxime axetil, a poorly water-soluble drug, using an …
prepare a nanosuspension of cefuroxime axetil, a poorly water-soluble drug, using an …
Optimization of Delivery and Bioavailability of Encapsulated Caffeic Acid
M Stanciauskaite, M Poskute, V Kurapkiene, M Marksa… - Foods, 2023 - mdpi.com
Caffeic acid is a widely distributed phenolic acid. It is described in the scientific literature that
caffeic acid has poor solubility. The aim of this study was to improve the solubility of caffeic …
caffeic acid has poor solubility. The aim of this study was to improve the solubility of caffeic …
Diacerein solid dispersion loaded tablets for minimization of drug adverse effects: statistical design, formulation, in vitro, and in vivo evaluation
MAN Soliman, HK Ibrahim… - Pharmaceutical …, 2021 - Taylor & Francis
Diacerein is a BCS class II drug employed in osteoarthritis management. The acid/base
hydrolysis of the unabsorbed diacerein in the colon is responsible for its laxative effect …
hydrolysis of the unabsorbed diacerein in the colon is responsible for its laxative effect …