Pulmonary surfactant: a mighty thin film

F Possmayer, YY Zuo, RAW Veldhuizen… - Chemical …, 2023 - ACS Publications
Pulmonary surfactant is a critical component of lung function in healthy individuals. It
functions in part by lowering surface tension in the alveoli, thereby allowing for breathing …

Alveolar lipids in pulmonary disease. A review

CW Agudelo, G Samaha, I Garcia-Arcos - Lipids in health and disease, 2020 - Springer
Lung lipid metabolism participates both in infant and adult pulmonary disease. The lung is
composed by multiple cell types with specialized functions and coordinately acting to meet …

The clinical use of corticosteroids in pregnancy

MW Kemp, JP Newnham, JG Challis… - Human reproduction …, 2016 - academic.oup.com
BACKGROUND The use of antenatal steroid therapy is common in pregnancy. In early
pregnancy, steroids may be used in women for the treatment of recurrent miscarriage or fetal …

[HTML][HTML] Structure-function relationships in pulmonary surfactant membranes: from biophysics to therapy

E Lopez-Rodriguez, J Pérez-Gil - Biochimica et Biophysica Acta (BBA) …, 2014 - Elsevier
Pulmonary surfactant is an essential lipid–protein complex to maintain an operative
respiratory surface at the mammalian lungs. It reduces surface tension at the alveolar air …

[HTML][HTML] Current perspectives in pulmonary surfactant—inhibition, enhancement and evaluation

YY Zuo, RAW Veldhuizen, AW Neumann… - … et Biophysica Acta (BBA …, 2008 - Elsevier
Pulmonary surfactant (PS) is a complicated mixture of approximately 90% lipids and 10%
proteins. It plays an important role in maintaining normal respiratory mechanics by reducing …

[HTML][HTML] Dysregulation of metabolic pathways in pulmonary fibrosis

R Rajesh, R Atallah, T Bärnthaler - Pharmacology & Therapeutics, 2023 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is a chronic progressive disorder of unknown origin and
the most common interstitial lung disease. It progresses with the recruitment of fibroblasts …

Lipid–protein and protein–protein interactions in the pulmonary surfactant system and their role in lung homeostasis

O Cañadas, B Olmeda, A Alonso… - International journal of …, 2020 - mdpi.com
Pulmonary surfactant is a lipid/protein complex synthesized by the alveolar epithelium and
secreted into the airspaces, where it coats and protects the large respiratory air–liquid …

[HTML][HTML] Restoring pulmonary surfactant membranes and films at the respiratory surface

M Echaide, C Autilio, R Arroyo, J Perez-Gil - Biochimica et Biophysica Acta …, 2017 - Elsevier
Pulmonary surfactant is a complex of lipids and proteins assembled and secreted by the
alveolar epithelium into the thin layer of fluid coating the respiratory surface of lungs. There …

Atomic force microscopy to study molecular mechanisms of amyloid fibril formation and toxicity in Alzheimer's disease

E Drolle, F Hane, B Lee, Z Leonenko - Drug metabolism reviews, 2014 - Taylor & Francis
Alzheimer's disease (AD) is a devastating neurodegenerative disease characterized by
dementia and memory loss for which no cure or effective prevention is currently available …

Combined and independent action of proteins SP-B and SP-C in the surface behavior and mechanical stability of pulmonary surfactant films

D Schürch, OL Ospina, A Cruz, J Pérez-Gil - Biophysical journal, 2010 - cell.com
The hydrophobic proteins SP-B and SP-C are essential for pulmonary surfactant function,
even though they are a relatively minor component (< 2% of surfactant dry mass). Despite …