Mechanisms of melanocyte death in vitiligo

J Chen, S Li, C Li - Medicinal Research Reviews, 2021 - Wiley Online Library
Vitiligo is an autoimmune depigment disease results from extensive melanocytes
destruction. The destruction of melanocyte is thought to be of multifactorial causation …

Janus kinase inhibitors in the treatment of vitiligo: a review

F Qi, F Liu, L Gao - Frontiers in immunology, 2021 - frontiersin.org
Vitiligo is a multifactorial reversible skin disorder characterized by distinct white patches that
result from melanocyte destruction. Activated CXCR3+ CD8+ T cells promote melanocyte …

Anatomically distinct fibroblast subsets determine skin autoimmune patterns

Z Xu, D Chen, Y Hu, K Jiang, H Huang, Y Du, W Wu… - Nature, 2022 - nature.com
The skin serves as a physical barrier and an immunological interface that protects the body
from the external environment,–. Aberrant activation of immune cells can induce common …

Update on the pathogenesis of vitiligo

HZ Marchioro, CCS Castro, VM Fava… - Anais Brasileiros de …, 2022 - SciELO Brasil
Vitiligo is a complex disease whose pathogenesis results from the interaction of genetic
components, metabolic factors linked to cellular oxidative stress, melanocyte adhesion to the …

Worldwide expert recommendations for the diagnosis and management of vitiligo: Position statement from the international Vitiligo Task Force—Part 2: Specific …

J Seneschal, R Speeckaert, A Taïeb… - Journal of the …, 2023 - Wiley Online Library
Background The treatment of vitiligo can be challenging. Up‐to‐date agreed consensus
recommendations on the use of topical and systemic therapies to facilitate the clinical …

The role of oxidative stress in vitiligo: an update on its pathogenesis and therapeutic implications

WL Chang, CH Ko - Cells, 2023 - mdpi.com
Vitiligo is an autoimmune skin disorder caused by dysfunctional pigment-producing
melanocytes which are attacked by immune cells. Oxidative stress is considered to play a …

An update on Vitiligo pathogenesis

J Seneschal, K Boniface, A D'Arino… - Pigment cell & …, 2021 - Wiley Online Library
Vitiligo, the most common depigmenting disorder of the skin, is undergoing a period of
intense advances in both disease understanding and therapeutic possibilities leading the …

Characteristics and pathogenesis of Koebner phenomenon

X Zhang, L Lei, L Jiang, C Fu, J Huang… - Experimental …, 2023 - Wiley Online Library
The Koebner phenomenon, also known as isomorphic reaction, refers to the development of
secondary lesions with the same clinical manifestations and histopathological …

Altered epidermal proliferation, differentiation, and lipid composition: Novel key elements in the vitiligo puzzle

D Kovacs, E Bastonini, S Briganti, M Ottaviani… - Science …, 2022 - science.org
Vitiligo is an acquired skin depigmentation disease involving multiple pathogenetic
mechanisms, which ultimately direct cytotoxic CD8+ cells to destroy melanocytes …

Current concepts of vitiligo immunopathogenesis

N Hlača, T Žagar, M Kaštelan, I Brajac, L Prpić-Massari - Biomedicines, 2022 - mdpi.com
Vitiligo is an acquired immune-mediated disorder of pigmentation clinically characterized by
well-defined depigmented or chalk-white macules and patches on the skin. The prevalence …