Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated
guidelines for the definition and interpretation of cell death from morphological, biochemical …

Mitochondria serve as a hub for a multitude of vital cellular processes. To ensure an efficient
deployment of mitochondrial tasks, organelle homeostasis needs to be preserved …

Mitochondria are highly dynamic organelles and important for a variety of cellular functions.
They constantly undergo fission and fusion events, referred to as mitochondrial dynamics …

Mitochondria continuously undergo two opposing processes, fission and fusion. The
disruption of this dynamic equilibrium may herald cell injury or death and may contribute to …

Excessive mitochondrial fission is associated with the pathology of a number of
neurodegenerative diseases. Therefore, inhibitors of aberrant mitochondrial fission could …

Mitochondria are remarkably dynamic organelles that migrate, divide and fuse. Cycles of
mitochondrial fission and fusion ensure metabolite and mitochondrial DNA mixing and …

Huntington's disease is an inherited and incurable neurodegenerative disorder caused by
an abnormal polyglutamine (polyQ) expansion in huntingtin (encoded by HTT). PolyQ length …

Apoptosis (programmed cell death) is a cellular self-destruction mechanism that is essential
for a variety of biological events, such as developmental sculpturing, tissue homeostasis …

Nitric oxide (NO) is an important signaling molecule that is widely used in the nervous
system. With recognition of its roles in synaptic plasticity (long-term potentiation, LTP; long …

NO and its derivatives can have multiple effects, which impact on neuronal death in different
ways. High levels of NO induces energy depletion-induced necrosis, due to:(i) rapid …