Ciliogenesis is a complex multistep process used to describe assembly of cilia and flagella.
These organelles play essential roles in motility and signaling on the surface of cells. Cilia …

The cilium evolved to provide the ancestral eukaryote with the ability to move and sense its
environment. Acquiring these functions required the compartmentalization of a dynein …

Ciliopathies manifest from sensory abnormalities to syndromic disorders with multi-organ
pathologies, with retinal degeneration a highly penetrant phenotype. Photoreceptor cell …

Inherited retinal dystrophies (IRDs) are congenital retinal degenerative diseases that have
various inheritance patterns, including dominant, recessive, X-linked, and mitochondrial …

Mechanoreceptor cells develop specialized mechanosensory organelles (MOs), where force-
sensitive channels and supporting structures are organized in an orderly manner to detect …

Cilia are highly conserved organelles critical for animal development and perception.
Dysfunction of cilia has been linked to a wide spectrum of human genetic diseases, termed …

The photoreceptor outer segment is a highly specialized primary cilium that is essential for
phototransduction and vision. Biallelic pathogenic variants in the cilia-associated gene …

Blindness poses a growing global challenge, with approximately 26% of cases attributed to
degenerative retinal diseases. While gene therapy, optogenetic tools, photosensitive …

Cilia play critical roles in cell signal transduction and organ development. Defects in cilia
function result in a variety of genetic disorders. Cep290 is an evolutionarily conserved …

Centrosomes are composed of centrioles surrounded by pericentriolar material. The two
centrioles in G1 phase are distinguished by the localization of their appendages in the distal …