Tumour necrosis factor (TNF) is a central cytokine in inflammatory reactions, and biologics
that neutralize TNF are among the most successful drugs for the treatment of chronic …

Regulated cell death mediated by dedicated molecular machines, known as programmed
cell death, plays important roles in health and disease. Apoptosis, necroptosis and …

The ability of cells to deal with different types of stressful situations in a precise and
coordinated manner is key for survival and involves various signalling networks. Over the …

Cell suicide pathways, termed regulated cell death (RCD), play a critical role in organismal
development, homeostasis, and pathogenesis. Here, we provide an overview of key RCD …

The concept of cell death has been expanded beyond apoptosis and necrosis to additional
forms, including necroptosis, pyroptosis, autophagy, and ferroptosis. These cell death …

Twelve regulated cell death programs have been described. We review in detail the basic
biology of nine including death receptor-mediated apoptosis, death receptor-mediated …

Apoptosis is crucial for the normal development of the nervous system, whereas neurons in
the adult CNS are relatively resistant to this form of cell death. However, under pathological …

Necroptosis refers to a regulated form of cell death induced by a variety of stimuli. Although it
has been implicated in the pathogenesis of many diseases, there is evidence to support that …

Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated
guidelines for the definition and interpretation of cell death from morphological, biochemical …

Cells may die from accidental cell death (ACD) or regulated cell death (RCD). ACD is a
biologically uncontrolled process, whereas RCD involves tightly structured signaling …