SUMMARY ATP-binding cassette (ABC) systems are universally distributed among living
organisms and function in many different aspects of bacterial physiology. ABC transporters …

Recent advances in solution NMR spectroscopy have significantly extended the spectrum of
problems that can now be addressed with this technology. In particular, studies of proteins …

Large-scale domain rearrangements in proteins have long been recognized to have a
critical function in ligand binding and recognition, catalysis and regulation,,,,. Crystal …

Protein solution nuclear magnetic resonance (NMR) can be conducted in a slightly
anisotropic environment, where the orientational distribution of the proteins is no longer …

Substrate-binding proteins (SBPs) are associated with ATP-binding cassette importers and
switch from an open to a closed conformation upon substrate binding, providing specificity …

The solution structure of Ca2+-ligated calmodulin is determined from residual dipolar
couplings measured in a liquid crystalline medium and from a large number of …

Because polyubiquitin chain structure modulates Ub-mediated signaling, knowledge of the
physiological conformations of chain signals should provide insights into specific …

Since the first applications of residual dipolar couplings (RDCs) to biomolecular systems
approximately a decade ago, RDCs have rapidly emerged as a standard tool for the …

▪ Abstract Recent developments in NMR spectroscopy, which include new experiments that
increase the lifetimes of NMR signals or that precisely define the orientation of internuclear …

Nuclear magnetic resonance (NMR) spectroscopy is now established as the method of
choice for the study of the structure and dynamics of proteins and nucleic acids in solution …