γ-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the vertebrate brain.
In the past, there has been a major research drive focused on the dysfunction of the …

The two amino acids GABA and glycine mediate fast inhibitory neurotransmission in different
CNS areas and serve pivotal roles in the spinal sensory processing. Under healthy …

Lamina II contains a large number of interneurons involved in modulation and transmission
of somatosensory (including nociceptive) information. However, its neuronal circuitry is …

We show that transsynaptic apoptosis is induced in the superficial dorsal horn (laminas I-III)
of the spinal cord by three distinct partial peripheral nerve lesions: spared nerve injury …

Environmental stimuli such as temperature and pressure are sensed by dorsal root ganglion
(DRG) neurons. DRG neurons are heterogeneous, but molecular markers that identify …

The 67 and 65 kDa isoforms of glutamic acid decarboxylase, the key enzymes for GABA
biosynthesis, are expressed at altered levels in postmortem brain of subjects diagnosed with …

Spinal cord injury induces maladaptive synaptic transmission in the somatosensory system
that results in chronic central neuropathic pain. Recent literature suggests that glial-neuronal …

Developmental studies identified four classes (V0, V1, V2, V3) of embryonic interneurons in
the ventral spinal cord. Very little is known, however, about their adult phenotypes …

Oligodendrocyte progenitor cells (OPCs) account for approximately 5% of the adult brain
and have been historically studied for their role in myelination. In the adult brain, OPCs …

Neuropathic pain is a chronic debilitating disease characterized by mechanical allodynia
and spontaneous pain. Because symptoms are often unresponsive to conventional methods …