PURPOSE The combination of whole-genome and transcriptome sequencing (WGTS) is
expected to transform diagnosis and treatment for patients with cancer. WGTS is a …

Simple Summary Multiple myeloma is an incurable blood cancer caused by the malignant
transformation of immunoglobulin-producing plasma cells. The mechanisms leading to the …

Lineage-ambiguous leukemias are high-risk malignancies of poorly understood genetic
basis. Here, we describe a distinct subgroup of acute leukemia with expression of myeloid, T …

Cytogenetics has long represented a critical component in the clinical evaluation of
hematologic malignancies. Chromosome banding studies provide a simultaneous snapshot …

Recently, MDS with mutated SF3B1 and blast count< 5% was proposed as distinct entity
with favorable prognosis by the international working group for the prognosis of MDS (IWG …

T cell–engaging immunotherapies exert unprecedented single-agent activity in multiple
myeloma (MM), thereby putting a yet unexplored selective pressure on the clonal …

In AML patients, recurrent mutations were shown to persist in remission, however, only some
have a prognostic value and persistent mutations might therefore reflect a re-established …

Introduction The suitability of whole-genome sequencing (WGS) as the sole method to
detect clinically relevant genomic aberrations in B-cell acute lymphoblastic leukemia (ALL) …

Molecular diagnostics as the centrepiece of precision oncology has gone through
revolutionary developments over the last decade, becoming tremendously broad, deep and …

Background Immunotherapeutic targets in multiple myeloma (MM) have variable expression
height and are partly expressed in subfractions of patients only. With increasing numbers of …