Lipoprotein lipase (LPL) is a multifunctional enzyme produced by many tissues, including
adipose tissue, cardiac and skeletal muscle, islets, and macrophages. LPL is the rate …

The field of cardiac tissue engineering has made significant strides over the last few
decades, highlighted by the development of human cell derived constructs that have shown …

In recent years, in-depth studies have shown that extracellular matrix stiffness plays an
important role in cell growth, proliferation, migration, immunity, malignant transformation …

The small heat shock protein Hsp27 or its murine homologue Hsp25 acts as an ATP-
independent chaperone in protein folding, but is also implicated in architecture of the …

The incidence of diabetes is increasing globally, with cardiovascular disease accounting for
a substantial number of diabetes-related deaths. Although atherosclerotic vascular disease …

Diabetic cardiomyopathy is a term used to describe cardiac muscle damage-induced heart
failure. Multiple structural and biochemical reasons have been suggested to induce this …

Worldwide, the prevalence of obesity and diabetes have increased, with heart disease being
their leading cause of death. Traditionally, the management of obesity and diabetes has …

Toll-like receptor (TLR) 4 regulates inflammation and metabolism and has been linked to the
pathogenesis of heart disease. TLR4 is upregulated in diabetic cardiomyocytes, and we …

Ninety percent of plasma fatty acids (FAs) are contained within lipoprotein-triglyceride, and
lipoprotein lipase (LPL) is robustly expressed in the heart. Hence, LPL-mediated lipolysis of …

Aims Autophagy is essential to maintain tissue homeostasis, particularly in long-lived cells
such as cardiomyocytes. Whereas many studies support the importance of autophagy in the …