Production of monoclonal antibodies for therapeutic purposes: A review

WP Alejandra, JPM Irene, GSF Antonio… - International …, 2023 - Elsevier
Monoclonal antibodies (mAbs) have been used in the development of immunotherapies that
target a variety of diseases, such as cancer, autoimmune diseases, and even viral infections; …

From cell line development to the formulated drug product: The art of manufacturing therapeutic monoclonal antibodies

SC Carrara, M Ulitzka, J Grzeschik, H Kornmann… - International Journal of …, 2021 - Elsevier
Therapeutic monoclonal antibodies and related products have steadily grown to become the
dominant product class within the biopharmaceutical market. Production of antibodies …

[HTML][HTML] Continuous precipitation of antibodies using oscillatory flow reactor: a proof of concept

D Ferreira-Faria, F Domingos-Moreira… - Separation and …, 2023 - Elsevier
Antibodies are among the most important drugs in the pharmaceutical industry. Their
increasing demand has pressured the industry to increase upstream antibody titers, making …

Current challenges and recent advances on the path towards continuous biomanufacturing

M Drobnjakovic, R Hart, B Kulvatunyou… - Biotechnology …, 2023 - Wiley Online Library
Continuous biopharmaceutical manufacturing is currently a field of intense research due to
its potential to make the entire production process more optimal for the modern, ever …

Peptide-crosslinked IgG-imprinted polymers for antibody capture and separation

Q Dong, M Yang, Z Zhao, Y Wang, Y Guan… - European Polymer …, 2023 - Elsevier
Downstream separation and purification of monoclonal antibodies (mAbs) has long been the
major bottleneck for their production. Here novel molecularly imprinted polymers (MIPs) of …

High throughput screening for rapid and reliable prediction of monovalent antibody binding behavior in flowthrough mode

JK Lorek, HS Karkov, F Matthiesen… - Biotechnology and …, 2024 - Wiley Online Library
Flowthrough (FT) anion exchange (AEX) chromatography is a widely used polishing step for
the purification of monoclonal antibody (mAb) formats. To accelerate downstream process …

CDMOs play a critical role in the biopharmaceutical ecosystem

H Kurata, T Ishino, Y Ohshima… - Frontiers in Bioengineering …, 2022 - frontiersin.org
Biopharmaceutical industries have advanced significantly after the millennium. Novel
biopharmaceuticals have been developed one after another, and blockbuster drugs have …

Monolithic affinity columns in 3D printed microfluidics for chikungunya RNA detection

JB Nielsen, JD Holladay, AJ Burningham… - Analytical and …, 2023 - Springer
Mosquito-borne pathogens plague much of the world, yet rapid and simple diagnosis is not
available for many affected patients. Using a custom stereolithography 3D printer, we …

Dual-recognition membrane Adsorbers combining hydrophobic charge-induction chromatography with surface imprinting via multicomponent reaction

M Guo, J Ye, C Zheng, J Meng - Journal of Chromatography A, 2022 - Elsevier
The combination of mixed-mode chromatography (MMC) and molecular imprinting
technology (MIT) has been proven to be successful for protein separation, but suffered from …

A Generic Antibody-Blocking Protein That Enables pH-Switchable Activation of Antibody Activity

L Biewenga, R Vermathen, BJHM Rosier… - ACS Chemical …, 2023 - ACS Publications
Molecular strategies that allow for reversible control of antibody activity have drawn
considerable interest for both therapeutic and diagnostic applications. Protein M is a generic …