Sepsis is a common complication of combat injuries and trauma, and is defined as a life-
threatening organ dysfunction caused by a dysregulated host response to infection. It is also …

Inflammasomes are critical sentinels of the innate immune system that respond to threats to
the host through recognition of distinct molecules, known as pathogen-or damage …

Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host
response to an infection. This recently implemented definition does not capture the …

High circulating levels of lactate and high mobility group box-1 (HMGB1) are associated with
the severity and mortality of sepsis. However, it is unclear whether lactate could promote …

Fifty years since the initial discovery of HMGB1 in 1973 as a structural protein of chromatin,
HMGB1 is now known to regulate diverse biological processes depending on its subcellular …

Abstract Toll-like receptor (TLR) 4 belongs to the TLR family of receptors inducing pro-
inflammatory responses to invading pathogens. TLR4 is activated by lipopolysaccharide …

Sepsis is defined as life-threatening organ dysfunction caused by dysregulated host
systemic inflammatory and immune response to infection. Over decades, advanced …

Canonically, gasdermin D (GSDMD) cleavage by caspase-1 through inflammasome
signaling triggers immune cell pyroptosis (ICP) as a host defense against pathogen …

The lung is a primary organ for gas exchange in mammals that represents the largest
epithelial surface in direct contact with the external environment. It also serves as a crucial …

Sepsis is defined as “a life-threatening organ dysfunction caused by a host's dysfunctional
response to infection”. Although the treatment of sepsis has developed rapidly in the past …