Emerging strategies for EphA2 receptor targeting for cancer therapeutics

M Tandon, SV Vemula, SK Mittal - Expert opinion on therapeutic …, 2011 - Taylor & Francis
Importance of the field: High mortality rates with cancers warrant further development of
earlier diagnostics and better treatment strategies. Membrane-bound erythropoietin …

Eph receptors and ephrins as targets for cancer therapy

HQ Xi, XS Wu, B Wei, L Chen - Journal of cellular and …, 2012 - Wiley Online Library
Eph receptor tyrosine kinases and their ephrin ligands are involved in various signalling
pathways and mediate critical steps of a wide variety of physiological and pathological …

EphA2 promotes epithelial–mesenchymal transition through the Wnt/β-catenin pathway in gastric cancer cells

J Huang, D Xiao, G Li, J Ma, P Chen, W Yuan, F Hou… - Oncogene, 2014 - nature.com
This study aims to investigate the significance of erythropoietin-producing hepatocellular
(Eph) A2 expression and the mechanism by which EphA2 is involved in the epithelial …

Ephrin-A2 promotes prostate cancer metastasis by enhancing angiogenesis and promoting EMT

Y Zhao, C Cai, M Zhang, L Shi, J Wang… - Journal of Cancer …, 2021 - Springer
Background Ephrin-A2, a member of the Eph receptor subgroup, is used in diagnosing and
determining the prognosis of prostate cancer. However, the role of ephrin-A2 in prostate …

Eph-dependent cell-cell adhesion and segregation in development and cancer

E Nievergall, M Lackmann, PW Janes - Cellular and Molecular Life …, 2012 - Springer
Numerous studies attest to essential roles for Eph receptors and their ephrin ligands in
controlling cell positioning and tissue patterning during normal and oncogenic development …

Immunotherapy against several tumors including gastrointestinal and gastric cancer

J Fritsche, T Weinschenk, S Walter… - US Patent …, 2015 - Google Patents
The present invention relates to peptides, nucleic acids and cells for use in
immunotherapeutic methods. In particular, the present invention relates to the …

The role of Eph receptors and ephrin ligands in colorectal cancer

NI Herath, AW Boyd - International Journal of Cancer, 2010 - Wiley Online Library
Eph receptors and their ephrin ligands constitute the largest subfamily of receptor tyrosine
kinases and are components of the cell signaling pathways involved during development …

EphA3 biology and cancer

PW Janes, CI Slape, RH Farnsworth, L Atapattu… - Growth …, 2014 - Taylor & Francis
Eph receptor tyrosine kinases control cell-cell interactions during normal and oncogenic
development, and are implicated in a range of processes including angiogenesis, stem cell …

EPHA2, EPHA4, and EPHA7 expression in triple-negative breast cancer

I Nikas, C Giaginis, K Petrouska, P Alexandrou… - Diagnostics, 2022 - mdpi.com
Ongoing research continues to elucidate the complex role of ephrin receptors (EPHs) and
their ligands (ephrins) in breast cancer pathogenesis, with their varying expression patterns …

Emerging therapeutic targets for gastric cancer from a host-Helicobacter pylori interaction perspective

E Abdi, S Latifi-Navid, F Abedi Sarvestani… - Expert opinion on …, 2021 - Taylor & Francis
Introduction Gastric cancer (GC) has the higher genetic, cytologic, and architectural
heterogeneity compared to other gastrointestinal cancers. By inducing gastric inflammation …