Traumatic spinal cord injury (SCI) is a devastating neurological condition that results in a
loss of motor and sensory function. Although extensive research to develop treatments for …

Discrimination between foreign and self antigens is necessary for normal immune function.
Whereas exposure to foreign antigens can lead to their elimination and subsequent specific …

Experimental autoimmune encephalomyelitis (EAE) is an animal model for autoimmune
central nervous system disease mediated by CD4 T cells. To examine the role of B cells in …

Experimental autoimmune encephalomyelitis (EAE) is a model of the neuroimmune system
responding to priming with central nervous system (CNS)-restricted antigens. It is an …

The ability to discriminate between self and nonself antigens is vital to the functioning of the
immune system as a specific defense against invading microorganisms. Failure of the …

Multiple sclerosis (MS) is the most frequent, demyelinating disease of the central nervous
system (CNS) in Northern Europeans and North Americans. Despite intensive research its …

Chronic relapsing paralysis and demyelination within the central nervous system (CNS),
features associated with the human disease multiple sclerosis (MS) 1–4, develop in mice …

The central nervous system has long been considered an immunologically privileged site.
Nevertheless, cells derived from the bone marrow can and do enter the CNS in a number of …

Recent advances in the preparation of synthetic peptide vaccines and the use of synthetic
peptides as probes of antigenic structure and function have led to renewed interest in the …

Susceptibility to neuroinflammatory disease is influenced in part by genetics. Recent data
indicate that survival of traumatized neurons is strain dependent and influenced by …