Highlights•Publications for drug repositioning have drastically increased in past five
years.•Different types of drug repositioning and available resources have been …

Treatments consisting of mixtures of pharmacological agents have been shown to have
superior effects to treatments involving single compounds. Given the vast amount of possible …

Drug-drug interaction (DDI) is a change in the effect of a drug when patient takes another
drug. Characterizing DDIs is extremely important to avoid potential adverse drug reactions …

Drug-drug interaction (DDI) is a vital information when physicians and pharmacists intend to
co-administer two or more drugs. Thus, several DDI databases are constructed to avoid …

In light of increased co-prescription of multiple drugs, the ability to discern and predict drug-
drug interactions (DDI) has become crucial to guarantee the safety of patients undergoing …

Identifying drug-drug interaction (DDI) is an important topic for the development of safe
pharmaceutical drugs and for the optimization of multidrug regimens for complex diseases …

Background: Bradycardia is a physiological condition characterized by a decrease in heart
rate and is a side effect of many drug classes. Bradycardia has been reported as an adverse …

Adverse drug–drug interactions (DDIs) can severely damage the body. Thus, it is essential
to accurately predict DDIs. DDIs are complex processes in which many factors can cause …

A natural and important generalization of submodularity–k-submodularity–applies to set
functions with k arguments and appears in a broad range of applications, such as …

As a medicine safety issue, Drug-Drug Interaction (DDI) may become an unexpected threat
for causing Adverse Drug Events (ADEs). There is a growing demand for computational …