The early endosome (EE), also known as the sorting endosome (SE) is a crucial station for
the sorting of cargoes, such as receptors and lipids, through the endocytic pathways. The …

Macropinocytosis is a regulated form of endocytosis that mediates the non‐selective uptake
of solute molecules, nutrients and antigens. It is an actin‐dependent process initiated from …

The mammalian genome encodes 49 proteins that possess a PX (phox-homology) domain,
responsible for membrane attachment to organelles of the secretory and endocytic system …

The endocytic network comprises a series of interconnected tubulo-vesicular membranous
compartments that together regulate various sorting and signalling events. Although it is …

Domains or modules known to bind phosphoinositides have increased dramatically in
number over the past few years, and are found in proteins involved in intracellular trafficking …

Phox homology (PX) domains are membrane interacting domains that bind to
phosphatidylinositol phospholipids or phosphoinositides, markers of organelle identity in the …

Abstract Background: Sorting nexins (SNXs) are phox homology (PX) domain-containing
proteins thought to regulate endosomal sorting of internalized receptors. The prototypical …

Sorting nexins are a diverse group of cellular trafficking proteins that are unified by the
presence of a phospholipid-binding motif—the PX domain. The ability of these proteins to …

Early endosome-to-trans-Golgi network (TGN) transport is organized by the retromer
complex. Consisting of cargo-selective and membrane-bound subcomplexes, retromer …

Protein trafficking requires coat complexes that couple recognition of sorting motifs in
transmembrane cargoes with biogenesis of transport carriers. The mechanisms of cargo …