Obstructive sleep apnea: transition from pathophysiology to an integrative disease model

WT McNicholas, D Pevernagie - Journal of sleep research, 2022 - Wiley Online Library
Obstructive sleep apnea (OSA) is characterised by recurring episodes of upper airway
obstruction during sleep and the fundamental abnormality reflects the inability of the upper …

International consensus statement on obstructive sleep apnea

JL Chang, AN Goldberg, JA Alt… - International forum of …, 2023 - Wiley Online Library
Background Evaluation and interpretation of the literature on obstructive sleep apnea (OSA)
allows for consolidation and determination of the key factors important for clinical …

Symptom subtypes of obstructive sleep apnea predict incidence of cardiovascular outcomes

DR Mazzotti, BT Keenan, DC Lim… - American journal of …, 2019 - atsjournals.org
Rationale: Symptom subtypes have been described in clinical and population samples of
patients with obstructive sleep apnea (OSA). It is unclear whether these subtypes have …

Phenotypic subtypes of OSA: a challenge and opportunity for precision medicine

A Zinchuk, HK Yaggi - Chest, 2020 - Elsevier
Current strategies for the management of OSA reflect a one-size-fits-all approach. Diagnosis
and severity of OSA are based on the apnea-hypopnea index and treatment initiated with …

[HTML][HTML] Co-morbid insomnia and sleep apnea (COMISA): prevalence, consequences, methodological considerations, and recent randomized controlled trials

A Sweetman, L Lack, C Bastien - Brain Sciences, 2019 - mdpi.com
Co-morbid insomnia and sleep apnea (COMISA) is a highly prevalent and debilitating
disorder, which results in additive impairments to patients' sleep, daytime functioning, and …

Sleep and sleep disorders in the menopausal transition

FC Baker, L Lampio, T Saaresranta… - Sleep medicine …, 2018 - sleep.theclinics.com
Sleep disturbances increase in prevalence during the menopausal transition, with the most
common complaint being nighttime awakenings. 1, 2 Sleep disturbances impact health …

Randomized clinical trials of cardiovascular disease in obstructive sleep apnea: understanding and overcoming bias

AI Pack, UJ Magalang, B Singh, ST Kuna, BT Keenan… - Sleep, 2021 - academic.oup.com
Three recent randomized control trials (RCTs) found that treatment of obstructive sleep
apnea (OSA) with continuous positive airway pressure (CPAP) did not reduce rates of future …

Recognizable clinical subtypes of obstructive sleep apnea across international sleep centers: a cluster analysis

BT Keenan, J Kim, B Singh, L Bittencourt, NH Chen… - Sleep, 2018 - academic.oup.com
Study Objectives A recent study of patients with moderate–severe obstructive sleep apnea
(OSA) in Iceland identified three clinical clusters based on symptoms and comorbidities. We …

More than the sum of the respiratory events: personalized medicine approaches for obstructive sleep apnea

BA Edwards, S Redline, SA Sands… - American journal of …, 2019 - atsjournals.org
Traditionally, the presence and severity of obstructive sleep apnea (OSA) have been defined
by the apnea–hypopnea index (AHI). Continuous positive airway pressure is generally first …

[HTML][HTML] CPAP therapy termination rates by OSA phenotype: a French nationwide database analysis

JL Pépin, S Bailly, P Rinder, D Adler, D Szeftel… - Journal of clinical …, 2021 - mdpi.com
The nationwide claims data lake for sleep apnoea (ALASKA)—real-life data for
understanding and increasing obstructive sleep apnea (OSA) quality of care study …