[HTML][HTML] The hallmarks of aging
Aging is characterized by a progressive loss of physiological integrity, leading to impaired
function and increased vulnerability to death. This deterioration is the primary risk factor for …
function and increased vulnerability to death. This deterioration is the primary risk factor for …
Molecular damage in aging
Cellular metabolism and environmental interactions generate molecular damage affecting
all levels of biological organization. Accumulation of this damage over time is thought to …
all levels of biological organization. Accumulation of this damage over time is thought to …
[HTML][HTML] Clonal dynamics of haematopoiesis across the human lifespan
E Mitchell, M Spencer Chapman, N Williams… - Nature, 2022 - nature.com
Age-related change in human haematopoiesis causes reduced regenerative capacity,
cytopenias, immune dysfunction and increased risk of blood cancer,–, but the reason for …
cytopenias, immune dysfunction and increased risk of blood cancer,–, but the reason for …
[HTML][HTML] Chronic infection drives Dnmt3a-loss-of-function clonal hematopoiesis via IFNγ signaling
D Hormaechea-Agulla, KA Matatall, DT Le, B Kain… - Cell stem cell, 2021 - cell.com
Age-related clonal hematopoiesis (CH) is a risk factor for malignancy, cardiovascular
disease, and all-cause mortality. Somatic mutations in DNMT3A are drivers of CH, but …
disease, and all-cause mortality. Somatic mutations in DNMT3A are drivers of CH, but …
Clonal hematopoiesis, with and without candidate driver mutations, is common in the elderly
F Zink, SN Stacey, GL Norddahl… - Blood, The Journal …, 2017 - ashpublications.org
Clonal hematopoiesis (CH) arises when a substantial proportion of mature blood cells is
derived from a single dominant hematopoietic stem cell lineage. Somatic mutations in …
derived from a single dominant hematopoietic stem cell lineage. Somatic mutations in …
The evolutionary dynamics and fitness landscape of clonal hematopoiesis
Somatic mutations acquired in healthy tissues as we age are major determinants of cancer
risk. Whether variants confer a fitness advantage or rise to detectable frequencies by chance …
risk. Whether variants confer a fitness advantage or rise to detectable frequencies by chance …
Clonal haematopoiesis harbouring AML-associated mutations is ubiquitous in healthy adults
AL Young, GA Challen, BM Birmann… - Nature communications, 2016 - nature.com
Clonal haematopoiesis is thought to be a rare condition that increases in frequency with age
and predisposes individuals to haematological malignancy. Recent studies, utilizing next …
and predisposes individuals to haematological malignancy. Recent studies, utilizing next …
Single-cell RNA-seq reveals changes in cell cycle and differentiation programs upon aging of hematopoietic stem cells
Both intrinsic cell state changes and variations in the composition of stem cell populations
have been implicated as contributors to aging. We used single-cell RNA-seq to dissect …
have been implicated as contributors to aging. We used single-cell RNA-seq to dissect …
Leukemia-associated somatic mutations drive distinct patterns of age-related clonal hemopoiesis
Clonal hemopoiesis driven by leukemia-associated gene mutations can occur without
evidence of a blood disorder. To investigate this phenomenon, we interrogated 15 mutation …
evidence of a blood disorder. To investigate this phenomenon, we interrogated 15 mutation …
Analysis of the genetic phylogeny of multifocal prostate cancer identifies multiple independent clonal expansions in neoplastic and morphologically normal prostate …
Genome-wide DNA sequencing was used to decrypt the phylogeny of multiple samples from
distinct areas of cancer and morphologically normal tissue taken from the prostates of three …
distinct areas of cancer and morphologically normal tissue taken from the prostates of three …