Abstract Turnbull, Andrew V., and Catherine L. Rivier. Regulation of the Hypothalamic-
Pituitary-Adrenal Axis by Cytokines: Actions and Mechanisms of Action. Physiol. Rev. 79: 1 …

Prostaglandin endoperoxide H synthases (PGHSs) 1 catalyze the conversion of arachidonic
acid and O2 to PGH2, the committed step in prostanoid biosynthesis (Fig. 1)(1). Before 1991 …

Prostaglandins play important and diverse roles in the CNS. The first step in prostaglandin
synthesis involves enzymatic oxidation of arachidonic acid, which is catalyzed by …

Murine prostaglandin endoperoxide (PGH) synthase-1 and PGH synthase-2 expressed in
cos-1 cells were found to be differentially sensitive to inhibition by common nonsteroidal anti …

Aspirin, arguably the world's favourite drug, has been around since the late nineteenth
century, but it wasn't until the late 1970s that its ability to inhibit prostaglandin production by …

Despite the molecular and histological similarities between fetal bone development and
fracture healing, inflammation is an early phase of fracture healing that does not occur …

The prostaglandin endoperoxide H synthase isoform 2, cyclooxygenase 2 (COX-2), is
induced at high levels in migratory and other responding cells by proinflammatory stimuli …

Prostaglandins formed by the cyclooxygenase (COX) enzymes are important mediators of
inflammation in arthritis. The contribution of the inducible COX-2 enzyme to inflammation in …

High levels of immunoreactive cyclooxygenase (Cox; prostaglandin H synthase) are present
in synovia from patients with rheumatoid arthritis (RA). We now show that the recently …

Publisher Summary The chapter compares and contrasts the structural and kinetic
properties of prostaglandin endoperoxide H synthase-1 (PGHS-1) and-2. It also discusses …